2023
Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders
Koller D, Pathak G, Wendt F, Tylee D, Levey D, Overstreet C, Gelernter J, Taylor H, Polimanti R. Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. JAMA Network Open 2023, 6: e2251214. PMID: 36652249, PMCID: PMC9856929, DOI: 10.1001/jamanetworkopen.2022.51214.Peer-Reviewed Original ResearchConceptsPsychiatric comorbidityMAIN OUTCOMEMental healthIrritable bowel syndromeBody mass indexAssociation of endometriosisOdds of depressionSevere physical symptomsPain-related phenotypesWomen's mental healthMultivariate regression analysisOdds of endometriosisBowel syndromeGenetic associationMass indexGynecologic pathologyMillion Veteran ProgramEndometriosisPsychiatric disordersWomen's healthFemale controlsPleiotropic mechanismsPhysical symptomsComorbiditiesFinnGen study
2020
Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program
Levey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF, Stein M. Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. American Journal Of Psychiatry 2020, 177: 223-232. PMID: 31906708, PMCID: PMC7869502, DOI: 10.1176/appi.ajp.2019.19030256.Peer-Reviewed Original ResearchConceptsNovel genome-wide significant associationsGene expressionGenome-wide significant signalsGenome-wide significant associationMillion Veteran ProgramWide association studyGenetic risk lociSignificant genetic correlationsGenetic risk mechanismsGenetic architectureGlobal regulatorChromosome 3Risk lociChromosome 6Chromosome 7Association studiesLargest GWASLarge biobanksGlobal regulationGenetic correlationsContinuous traitsVeteran ProgramGWASsLociPrevious GWASs
2017
Genetic risk variants for social anxiety
Stein MB, Chen C, Jain S, Jensen KP, He F, Heeringa SG, Kessler RC, Maihofer A, Nock MK, Ripke S, Sun X, Thomas ML, Ursano RJ, Smoller JW, Gelernter J, Collaborators O. Genetic risk variants for social anxiety. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 174: 120-131. PMID: 28224735, PMCID: PMC5325045, DOI: 10.1002/ajmg.b.32520.Peer-Reviewed Original Research
2011
Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates
Jackowski A, Perera TD, Abdallah CG, Garrido G, Tang CY, Martinez J, Mathew SJ, Gorman JM, Rosenblum LA, Smith EL, Dwork AJ, Shungu DC, Kaffman A, Gelernter J, Coplan JD, Kaufman J. Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates. Psychiatry Research 2011, 192: 37-44. PMID: 21377844, PMCID: PMC4090111, DOI: 10.1016/j.pscychresns.2010.11.006.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnxietyBehavior, AnimalBrain MappingCorpus CallosumCross-Sectional StudiesFearGene FrequencyGenotypeHippocampusImage Processing, Computer-AssistedLinear ModelsMacaca radiataMagnetic Resonance ImagingMaleSerotonin Plasma Membrane Transport ProteinsStress, PsychologicalConceptsBrain developmentNonhuman primatesCorpus callosum measurementsMale bonnet monkeysMiddle temporal gyrus volumeCorpus callosum developmentMale nonhuman primatesEarly life stressReduced hippocampusCorpus callosumMRI measuresBonnet monkeysPsychiatric disordersMRI scansHippocampal volumetricsSerotonin transporter genotypeCC sizeStress paradigmHippocampusStress reactivityMorphometry assessmentBehavioral assessmentTransporter genotypeAnxious behaviorEarly stress
2007
Gene-by-Environment (Serotonin Transporter and Childhood Maltreatment) Interaction for Anxiety Sensitivity, an Intermediate Phenotype for Anxiety Disorders
Stein MB, Schork NJ, Gelernter J. Gene-by-Environment (Serotonin Transporter and Childhood Maltreatment) Interaction for Anxiety Sensitivity, an Intermediate Phenotype for Anxiety Disorders. Neuropsychopharmacology 2007, 33: 312-319. PMID: 17460615, DOI: 10.1038/sj.npp.1301422.Peer-Reviewed Original Research
2006
Genome Scan for Loci Predisposing to Anxiety Disorders Using a Novel Multivariate Approach: Strong Evidence for a Chromosome 4 Risk Locus
Kaabi B, Gelernter J, Woods SW, Goddard A, Page GP, Elston RC. Genome Scan for Loci Predisposing to Anxiety Disorders Using a Novel Multivariate Approach: Strong Evidence for a Chromosome 4 Risk Locus. American Journal Of Human Genetics 2006, 78: 543-553. PMID: 16532386, PMCID: PMC1424685, DOI: 10.1086/501072.Peer-Reviewed Original Research
2005
COMT Polymorphisms and Anxiety-Related Personality Traits
Stein MB, Fallin MD, Schork NJ, Gelernter J. COMT Polymorphisms and Anxiety-Related Personality Traits. Neuropsychopharmacology 2005, 30: 2092-2102. PMID: 15956988, DOI: 10.1038/sj.npp.1300787.Peer-Reviewed Original ResearchAdolescentAdultAnxietyCatechol O-MethyltransferaseChi-Square DistributionConfidence IntervalsDemographyExtraversion, PsychologicalFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansMaleMethionineNeurotic DisordersOdds RatioPersonalityPersonality InventoryPolymorphism, GeneticSex FactorsValine