2017
Genetic and psychosocial predictors of alcohol use trajectories among disaster‐exposed adolescents
Bountress K, Danielson CK, Williamson V, Vladmirov V, Gelernter J, Ruggiero K, Amstadter A. Genetic and psychosocial predictors of alcohol use trajectories among disaster‐exposed adolescents. American Journal On Addictions 2017, 26: 623-631. PMID: 28594439, PMCID: PMC5627968, DOI: 10.1111/ajad.12575.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAdolescent BehaviorAlcohol DrinkingDisastersFemaleGenetic Association StudiesGenome-Wide Association StudyHumansMalePsychological TechniquesRisk FactorsSocial SupportSouth CarolinaStress Disorders, Post-TraumaticStress, PsychologicalTrauma Severity IndicesConceptsDisaster-exposed adolescentsAdolescent alcohol misuseAlcohol use trajectoriesPTSD symptomsEmotional supportAlcohol misuseDisaster exposurePosttraumatic stress disorder (PTSD) symptomsAdolescent PTSD symptomsMore PTSD symptomsAlcohol useUse trajectoriesAlcohol use/misuseAlcohol use outcomesCommunity/familyUse/misuseWeb-based interventionDisorder symptomsPsychosocial predictorsSeverity of exposureUse outcomesAdolescentsGenetic riskCurrent studyLong-term adverse outcomes
2013
Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults
White S, Acierno R, Ruggiero KJ, Koenen KC, Kilpatrick DG, Galea S, Gelernter J, Williamson V, McMichael O, Vladimirov VI, Amstadter AB. Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults. Journal Of Anxiety Disorders 2013, 27: 678-683. PMID: 24077033, PMCID: PMC4182958, DOI: 10.1016/j.janxdis.2013.08.003.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPTSD symptomsHormone receptor 1 geneCorticotropin-releasing hormone receptor 1 (CRHR1) geneSingle nucleotide polymorphismsReceptor 1 geneCRHR1 variationEtiology of PTSDHPA axisAdrenal axisCRHR1 variantsPosttraumatic stress symptomsStress disorderAnxiety disordersFinal analysisSymptomsHeritable anxiety disordersEuropean-American subsampleAdultsStress symptomsCRHR1Genetic variantsMultiple testingDiagnosisDisorders
2012
Examining the relation between the serotonin transporter 5-HTTPLR genotype x trauma exposure interaction on a contemporary phenotypic model of posttraumatic stress symptomatology: A pilot study
Pietrzak RH, Galea S, Southwick SM, Gelernter J. Examining the relation between the serotonin transporter 5-HTTPLR genotype x trauma exposure interaction on a contemporary phenotypic model of posttraumatic stress symptomatology: A pilot study. Journal Of Affective Disorders 2012, 148: 123-128. PMID: 23183127, PMCID: PMC3604029, DOI: 10.1016/j.jad.2012.11.003.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overCyclonic StormsDisastersFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedModels, GeneticPhenotypePilot ProjectsPolymorphism, GeneticQualitative ResearchSerotonin Plasma Membrane Transport ProteinsStress Disorders, Post-TraumaticYoung Adult
2009
Association Between COMT, PTSD, and Increased Smoking Following Hurricane Exposure in an Epidemiologic Sample
Amstadter AB, Nugent NR, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. Association Between COMT, PTSD, and Increased Smoking Following Hurricane Exposure in an Epidemiologic Sample. Psychiatry 2009, 72: 360-369. PMID: 20070134, PMCID: PMC2808117, DOI: 10.1521/psyc.2009.72.4.360.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCigarette smokingCOMT Val158MetFrequency of smokingSaliva DNA samplesFirst genetic association studyFlorida Hurricane StudyAge of initiationCOMT Val158Met polymorphismTobacco smokingSmokingEpidemiologic samplePossible associationAcute stressorStress disorderVal158Met polymorphismHurricane exposureTraumatic eventsGenetic association studiesVal158MetAssociationEuropean American malesDNA samplesAssociation studiesInitiation
2007
The Serotonin Transporter Genotype and Social Support and Moderation of Posttraumatic Stress Disorder and Depression in Hurricane-Exposed Adults
Kilpatrick DG, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Resnick HS, Roitzsch J, Boyle J, Gelernter J. The Serotonin Transporter Genotype and Social Support and Moderation of Posttraumatic Stress Disorder and Depression in Hurricane-Exposed Adults. American Journal Of Psychiatry 2007, 164: 1693-1699. PMID: 17974934, DOI: 10.1176/appi.ajp.2007.06122007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersDisastersFemaleFloridaGenetic VariationGenotypeHumansLife Change EventsLogistic ModelsMaleMiddle AgedPolymorphism, GeneticPsychiatric Status Rating ScalesRisk FactorsSerotonin Plasma Membrane Transport ProteinsSocial SupportStress Disorders, Post-TraumaticConceptsHigh hurricane exposurePosttraumatic stress disorderLow social supportMajor depressionLow-expression variantPostdisaster posttraumatic stress disorderSocial supportStress disorderHurricane exposureHigh-risk individualsDSM-IV diagnosisLow-risk individualsAdults ages 18Household probability sampleSubset of participantsOutcome measuresAdults 6Serotonin transporter genotypeSerotonin transporter geneAge 18DepressionDisaster exposureTransporter genotypeRiskStructured interviews