2022
Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans
Tamman AJF, Nagamatsu S, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Pietrzak RH. Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans. American Journal Of Geriatric Psychiatry 2022, 31: 97-109. PMID: 36210262, DOI: 10.1016/j.jagp.2022.09.002.Peer-Reviewed Original ResearchConceptsRisk factorsPremature mortalityU.S. veteransPsychosocial variablesNovel epigenetic clockLifetime substance use disorderRisk stratification modelMale U.S. veteransCross-sectional studyU.S. veteran populationWeekly physical exerciseSubstance use disordersMale U.S. military veteransBiological agingU.S. military veteransHealth morbidityModifiable correlatesMortality riskSleep qualityHigh riskGreater oddsUse disordersPhysical exercisePsychosocial factorsVeteran population
2009
Cognitive Flexibility is Associated with KIBRA Variant and Modulated by Recent Tobacco Use
Zhang H, Kranzler HR, Poling J, Gruen JR, Gelernter J. Cognitive Flexibility is Associated with KIBRA Variant and Modulated by Recent Tobacco Use. Neuropsychopharmacology 2009, 34: 2508-2516. PMID: 19606085, PMCID: PMC2898508, DOI: 10.1038/npp.2009.80.Peer-Reviewed Original ResearchConceptsCognitive flexibilityPerseverative errorsPerseverative responsesWisconsin Card Sorting TestMemory performance measuresCard Sorting TestSorting TestRs17070145Main effectInteraction effectsEuropean AmericansRecencyPopulation-specific wayRecent tobacco usePerformance measuresTobacco useSynaptic plasticityModeratesKIBRAAfrican AmericansSmokersFlexibility
2005
Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene.
van Dyck CH, Malison RT, Jacobsen LK, Seibyl JP, Staley JK, Laruelle M, Baldwin RM, Innis RB, Gelernter J. Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. Journal Of Nuclear Medicine 2005, 46: 745-51. PMID: 15872345.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAgingCocaineCorpus StriatumDopamine Plasma Membrane Transport ProteinsFemaleGene FrequencyGenetic TestingHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMicrosatellite RepeatsMiddle AgedNerve Tissue ProteinsPolymorphism, GeneticRadionuclide ImagingRadiopharmaceuticalsTissue DistributionConceptsStriatal DAT availabilityDAT availabilityDopamine transporterDAT genotypeDopamine transporter availabilityBrain uptakeTransporter availabilityHealthy European AmericansDAT levelsCarbomethoxy-3betaClinical phenotypeMean increaseNeuropsychiatric diseasesSLC6A3 polymorphismsVNTR polymorphismSLC6A3European AmericansSLC6A3 geneHomozygotesHuman clinical phenotypesSubregion analysisPolymorphismDivergent resultsAssociationCommon alleles