2014
Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders
Kos MZ, Glahn DC, Carless MA, Olvera R, McKay DR, Quillen EE, Gelernter J, Chen X, Deng H, Kent JW, Dyer TD, Göring HH, Curran JE, Duggirala R, Blangero J, Almasy L. Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2014, 165: 294-302. PMID: 24692236, PMCID: PMC4172449, DOI: 10.1002/ajmg.b.32231.Peer-Reviewed Original ResearchConceptsSan Antonio Family StudyGenome-wide SNPsSignificant SNP associationsSignificant pleiotropic effectsCompelling candidate genesStrong genetic correlationPotential risk locusNovel QTLChromosome 6p22.3Significant QTLGene actionChromosome regionsChromosome 4Heritable phenotypesCandidate genesRisk lociLinkage signalChromosome 6p22QTLSNP associationsLinkage regionGenetic correlationsSusceptibility genesPleiotropic effectsGenes
2002
A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression
Ahn J, Won TW, Kaplan DE, Londin ER, Kuzmič P, Gelernter J, Gruen JR. A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression. Human Genetics 2002, 111: 339-349. PMID: 12384775, DOI: 10.1007/s00439-002-0771-x.Peer-Reviewed Original ResearchBase SequenceChromosomes, Human, Pair 6DNA PrimersGenetic MarkersGenotypeHumansPhysical Chromosome MappingRecombination, Genetic
2001
Suicide, impulsive aggression, and HTR1B genotype
New A, Gelernter J, Goodman M, Mitropoulou V, Koenigsberg H, Silverman J, Siever L. Suicide, impulsive aggression, and HTR1B genotype. Biological Psychiatry 2001, 50: 62-65. PMID: 11457425, DOI: 10.1016/s0006-3223(01)01108-8.Peer-Reviewed Original ResearchAdultAggressionCell Cycle ProteinsChromosomes, Human, Pair 6Disruptive, Impulse Control, and Conduct DisordersFemaleFungal ProteinsGenetic Predisposition to DiseaseGenotypeHumansMalePersonality DisordersPolymerase Chain ReactionPolymorphism, GeneticRepressor ProteinsRNA-Binding ProteinsSaccharomyces cerevisiae ProteinsSuicide, AttemptedHuman GABAB receptor 1 gene: Eight novel sequence variants
Hisama F, Gruen J, Choi J, Huseinovic M, Grigorenko E, Pauls D, Mattson R, Gelernter J, Wood F, Goei V. Human GABAB receptor 1 gene: Eight novel sequence variants. Human Mutation 2001, 17: 349-350. PMID: 11295833, DOI: 10.1002/humu.34.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 6DNA Mutational AnalysisDNA PrimersExonsGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHumansIntronsMental DisordersMutationMutation, MissensePolymorphism, GeneticPolymorphism, Restriction Fragment LengthPolymorphism, Single-Stranded ConformationalReceptors, GABA-BUnited StatesConceptsNeurobehavioral disordersPrincipal inhibitory neurotransmitterHuman leukocyte antigen (HLA) regionInhibitory neurotransmitterPharmacogenetic studiesGene mutationsAntigen regionIntron variantsMissense mutationsDistinct mutationsDisordersLinkage studiesReceptor mapsAmerican populationGABBR1MutationsSusceptibility regionsEpilepsyCandidate genesDNA variantsGABANeurotransmittersSchizophreniaBrain