2021
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, Kranzler H, Gelernter J, Harris K, Tucker-Drob E, Waldman I, Palmer A, Harden K, Koellinger P, Dick D. Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nature Neuroscience 2021, 24: 1367-1376. PMID: 34446935, PMCID: PMC8484054, DOI: 10.1038/s41593-021-00908-3.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityBehavior, AddictiveBehavioral SymptomsComputational BiologyCrimeGenetic Association StudiesGenome-Wide Association StudyHIV InfectionsHumansMeta-Analysis as TopicMultifactorial InheritanceMultivariate AnalysisOpioid-Related DisordersReproducibility of ResultsSelf-ControlSuicideUnemployment
2012
Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence
Zhang H, Herman AI, Kranzler HR, Anton RF, Simen AA, Gelernter J. Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence. Journal Of Human Genetics 2012, 57: 670-675. PMID: 22914673, PMCID: PMC3481015, DOI: 10.1038/jhg.2012.98.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCase-Control StudiesCocaine-Related DisordersComorbidityCpG IslandsDNA MethylationFemaleGenetic Predisposition to DiseaseGenetics, PopulationGenome, HumanHumansMaleMarijuana AbuseMiddle AgedMultivariate AnalysisPromoter Regions, GeneticReceptors, Opioid, muRisk FactorsSequence Analysis, DNAWhite PeopleConceptsChildhood adversityOPRM1 promoter regionAD casesΜ-opioid receptor geneSubstance dependence disordersΜ-opioid receptorDays of intoxicationEffects of alcoholEuropean American controlsPromoter methylation levelsPeripheral bloodMethylation levelsDependence disordersAlcohol dependenceMultivariate analysisPromoter regionPromoter hypermethylationReceptor geneIllicit drugsEuropean AmericansMultiple comparisonsBisulfite sequencing analysisOverall methylation levelsAmerican controlsSex
2009
Cognitive Flexibility is Associated with KIBRA Variant and Modulated by Recent Tobacco Use
Zhang H, Kranzler HR, Poling J, Gruen JR, Gelernter J. Cognitive Flexibility is Associated with KIBRA Variant and Modulated by Recent Tobacco Use. Neuropsychopharmacology 2009, 34: 2508-2516. PMID: 19606085, PMCID: PMC2898508, DOI: 10.1038/npp.2009.80.Peer-Reviewed Original ResearchConceptsCognitive flexibilityPerseverative errorsPerseverative responsesWisconsin Card Sorting TestMemory performance measuresCard Sorting TestSorting TestRs17070145Main effectInteraction effectsEuropean AmericansRecencyPopulation-specific wayRecent tobacco usePerformance measuresTobacco useSynaptic plasticityModeratesKIBRAAfrican AmericansSmokersFlexibilityGenetic variation in 5HTTLPR is associated with emotional resilience
Stein MB, Campbell‐Sills L, Gelernter J. Genetic variation in 5HTTLPR is associated with emotional resilience. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2009, 150B: 900-906. PMID: 19152387, PMCID: PMC2885845, DOI: 10.1002/ajmg.b.30916.Peer-Reviewed Original ResearchConceptsEmotional resilienceSelf-report measuresAdverse mental health outcomesMental health outcomesUndergraduate college studentsPsychological functioningIndividual differencesSerotonin transporter promoter polymorphismTransporter promoter polymorphismIndividual's abilityLife stressorsCollege studentsResilience
2006
Personality Traits of Agreeableness and Extraversion are Associated with ADH4 Variation
Luo X, Kranzler HR, Zuo L, Wang S, Gelernter J. Personality Traits of Agreeableness and Extraversion are Associated with ADH4 Variation. Biological Psychiatry 2006, 61: 599-608. PMID: 17069770, PMCID: PMC1853245, DOI: 10.1016/j.biopsych.2006.05.017.Peer-Reviewed Original ResearchGenome Scan for Loci Predisposing to Anxiety Disorders Using a Novel Multivariate Approach: Strong Evidence for a Chromosome 4 Risk Locus
Kaabi B, Gelernter J, Woods SW, Goddard A, Page GP, Elston RC. Genome Scan for Loci Predisposing to Anxiety Disorders Using a Novel Multivariate Approach: Strong Evidence for a Chromosome 4 Risk Locus. American Journal Of Human Genetics 2006, 78: 543-553. PMID: 16532386, PMCID: PMC1424685, DOI: 10.1086/501072.Peer-Reviewed Original Research
2004
Association study of personality factors and the Asn40Asp polymorphism at the μ-opioid receptor gene (OPRM1)
Hernandez-Avila CA, Covault J, Gelernter J, Kranzler HR. Association study of personality factors and the Asn40Asp polymorphism at the μ-opioid receptor gene (OPRM1). Psychiatric Genetics 2004, 14: 89-92. PMID: 15167694, DOI: 10.1097/01.ypg.0000107931.32051.c7.Peer-Reviewed Original ResearchConceptsMu-opioid receptor proteinΜ-opioid receptor geneSubstance-dependent subjectsAsn40Asp polymorphismSubstance dependence diagnosesHealthy subjectsAllelic associationBlood samplesDependence diagnosisDiagnostic InterviewDemographic featuresExtracellular domainFunctional polymorphismsReceptor geneReceptor extracellular domainReceptor proteinAssociationNEO-Five Factor InventorySubjectsAssociation studiesFive-Factor InventoryPolymorphismAsn40AspPersonality factorsDiagnosis