2014
The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder
Jensen KP, Stein MB, Kranzler HR, Yang BZ, Farrer LA, Gelernter J. The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder. Translational Psychiatry 2014, 4: e353-e353. PMID: 24473444, PMCID: PMC3905232, DOI: 10.1038/tp.2013.122.Peer-Reviewed Original ResearchConceptsPanic disorderAnxiety disordersCocaine-induced paranoiaAnxiety disorder casesWhole blood cellsPsychiatric disorder riskWarrants further investigationAfrican American subjectsComorbid drugPD casesPsychiatric disordersAlcohol dependenceBrain tissueCocaine useBehavioral effectsBlood cellsClinical potentialGene variantsDisordersDisorder casesSingle nucleotide polymorphismsDisorder riskIndependent samplesPsychiatric phenotypesFurther investigation
2009
Association of Variants in MANEA With Cocaine-Related Behaviors
Farrer LA, Kranzler HR, Yu Y, Weiss RD, Brady KT, Anton R, Cubells JF, Gelernter J. Association of Variants in MANEA With Cocaine-Related Behaviors. JAMA Psychiatry 2009, 66: 267-274. PMID: 19255376, PMCID: PMC2758158, DOI: 10.1001/archgenpsychiatry.2008.538.Peer-Reviewed Original ResearchTwenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity
Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA. Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity. Pharmacogenetics And Genomics 2009, 19: 53-65. PMID: 19077666, PMCID: PMC2791799, DOI: 10.1097/fpc.0b013e328318b21a.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnimalsBase SequenceBlack or African AmericanCase-Control StudiesCell LineDNA PrimersEnhancer Elements, GeneticFemaleGABA Plasma Membrane Transport ProteinsGene ExpressionHippocampusHumansMaleMiceMiddle AgedMinisatellite RepeatsMolecular Sequence DataMutagenesis, InsertionalPharmacogeneticsPolymorphism, GeneticPromoter Regions, GeneticRecombinant ProteinsRNA, MessengerSchizophreniaSequence Homology, Nucleic AcidTranscriptional ActivationYoung Adult
2006
γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment
Krystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Gelernter J, Lappalainen J. γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment. JAMA Psychiatry 2006, 63: 957-968. PMID: 16952998, DOI: 10.1001/archpsyc.63.9.957.Peer-Reviewed Original ResearchConceptsBrain GABA systemsGABA systemAlcohol dependenceWithdrawal symptomsGABA functionGamma-aminobutyric acid (GABA) functionCortical GABA levelsAlcohol withdrawal symptomsΓ-Aminobutyric Acid Type A ReceptorsEnvironmental risk factorsLong-term alcohol effectsType A ReceptorsAlcohol-dependent individualsLong-term sobrietyGABA releaseNeurosteroid levelsAcute withdrawalAlcoholism vulnerabilityGABA neurotransmissionRisk factorsGABA levelsExtrasynaptic locationsLow chloride conductanceReceptor densityTonic component