2009
BDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: An Exploratory Study
Zdanys KF, Kleiman TG, Zhang H, Ozbay F, MacAvoy MG, Gelernter J, van Dyck CH. BDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: An Exploratory Study. Journal Of Alzheimer's Disease 2009, 17: 887-898. PMID: 19542613, PMCID: PMC4084650, DOI: 10.3233/jad-2009-1106.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAllelesAlzheimer DiseaseBrain-Derived Neurotrophic FactorCognitionDisease ProgressionEducational StatusFemaleGene FrequencyGenetic Predisposition to DiseaseHallucinationsHumansMalePolymerase Chain ReactionPolymorphism, Single NucleotidePrevalenceRetrospective StudiesSeverity of Illness IndexConceptsBrain-derived neurotrophic factorNeuropsychiatric symptomsAlzheimer's diseaseBDNF polymorphismFunctional declineRole of BDNFMultiple subsequent time pointsVal/Val groupBDNF genetic variantsC270T polymorphismPresence of hallucinationsMet/MetSubsequent time pointsVal/MetBDNF variantsClinical courseVal66Met genotypeVal66Met polymorphismC270TDisease characteristicsNeurotrophic factorTests of cognitionNeuronal survivalAD patientsHigh prevalence
2008
Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder
Chepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder. Neuropsychopharmacology 2008, 34: 944-951. PMID: 18704093, PMCID: PMC2837582, DOI: 10.1038/npp.2008.107.Peer-Reviewed Original ResearchConceptsSmaller hippocampus volumesHippocampus volumeBipolar disorderBDNF genotypeBD diagnosisMood disorder pathophysiologyBDNF Val66Met polymorphismHigh-resolution magnetic resonanceHealthy comparison subjectsVal/Val homozygotesEffect of diagnosisLinear mixed model analysisVal66Met polymorphismGrowth factor proteinBD subgroupsDisorder pathophysiologyHC subjectsHippocampal developmentComparison subjectsMixed model analysisHippocampus structureBDNFHippocampus morphologyAnterior hippocampusVal homozygotes