2009
BDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: An Exploratory Study
Zdanys KF, Kleiman TG, Zhang H, Ozbay F, MacAvoy MG, Gelernter J, van Dyck CH. BDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: An Exploratory Study. Journal Of Alzheimer's Disease 2009, 17: 887-898. PMID: 19542613, PMCID: PMC4084650, DOI: 10.3233/jad-2009-1106.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAllelesAlzheimer DiseaseBrain-Derived Neurotrophic FactorCognitionDisease ProgressionEducational StatusFemaleGene FrequencyGenetic Predisposition to DiseaseHallucinationsHumansMalePolymerase Chain ReactionPolymorphism, Single NucleotidePrevalenceRetrospective StudiesSeverity of Illness IndexConceptsBrain-derived neurotrophic factorNeuropsychiatric symptomsAlzheimer's diseaseBDNF polymorphismFunctional declineRole of BDNFMultiple subsequent time pointsVal/Val groupBDNF genetic variantsC270T polymorphismPresence of hallucinationsMet/MetSubsequent time pointsVal/MetBDNF variantsClinical courseVal66Met genotypeVal66Met polymorphismC270TDisease characteristicsNeurotrophic factorTests of cognitionNeuronal survivalAD patientsHigh prevalence
2006
Apolipoprotein E ε4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer’s Disease: Retrospective and Prospective Analysis
Kleiman T, Zdanys K, Black B, Rightmer T, Grey M, Garman K, MacAvoy M, Gelernter J, van Dyck C. Apolipoprotein E ε4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer’s Disease: Retrospective and Prospective Analysis. Dementia And Geriatric Cognitive Disorders 2006, 22: 73-82. PMID: 16699282, DOI: 10.1159/000093316.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseFunctional declineProspective analysisAD patientsEpsilon4 doseMultiple subsequent time pointsApolipoprotein E (APOE) ε4 alleleGenotype groupsApolipoprotein E epsilon4 alleleDuration of symptomsAD patient samplesGenetic risk factorsSubsequent time pointsTests of cognitionRisk factorsAPOE epsilon4Disease onsetDisease progressionEpsilon4 alleleFunctional impairmentRetrospective analysisΕ4 alleleDaily functionPatient samplesFunctional measures