Multivariate Pattern Analysis of Genotype–Phenotype Relationships in Schizophrenia
Zheutlin AB, Chekroud AM, Polimanti R, Gelernter J, Sabb FW, Bilder RM, Freimer N, London ED, Hultman CM, Cannon TD. Multivariate Pattern Analysis of Genotype–Phenotype Relationships in Schizophrenia. Schizophrenia Bulletin 2018, 44: 1045-1052. PMID: 29534239, PMCID: PMC6101611, DOI: 10.1093/schbul/sby005.Peer-Reviewed Original ResearchConceptsMultivariate pattern analysisIndependent samplesVisual memoryCognitive endophenotypesPredictive strengthSchizophreniaMemoryIndividual variationPattern analysisSingle predictorCertain domainsDiscovery samplePsychiatric patientsPolygenic risk scoresPredictive powerScoresEndophenotypesPotential relationshipRelationshipRandom forestGenetic risk variantsLimited setPredictorsComprehensive setSamples