2024
POST-GWAS FOR PTSD: FROM RISK LOCI TO BIOLOGICAL MEANING
Nievergelt C, Ongeri L, Gelernter J. POST-GWAS FOR PTSD: FROM RISK LOCI TO BIOLOGICAL MEANING. European Neuropsychopharmacology 2024, 87: 2-3. DOI: 10.1016/j.euroneuro.2024.08.013.Peer-Reviewed Original ResearchPosttraumatic stress disorderPGC-PTSDLocal ancestry inferencePTSD associationsRisk lociPosttraumatic stress disorder casenessThreat-related processingGenome-wide association study resultsCo-morbid disordersComplex patterns of admixtureStress-related disordersMental health disordersPatterns of admixturePotential causal genesMajor histocompatibility complexMental health consequencesAssociation study resultsMDD patientsMulti-omics approachStress disorderMulti-omics studiesHuman leukocyte antigenAncestry inferenceAdmixed individualsMDD
2022
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Lynall ME, Soskic B, Hayhurst J, Schwartzentruber J, Levey DF, Pathak GA, Polimanti R, Gelernter J, Stein MB, Trynka G, Clatworthy MR, Bullmore E. Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells. Nature Communications 2022, 13: 6102. PMID: 36243721, PMCID: PMC9569335, DOI: 10.1038/s41467-022-33885-7.Peer-Reviewed Original ResearchConceptsMultiple psychiatric disordersPsychiatric disordersPsychiatric risk variantT cellsLymphoid cellsRisk variantsImmune cell subsetsMental health disordersMultiple organ systemsAdaptive immune systemCell subsetsImmune cellsHealth disordersMyeloid cellsImmune systemBrain tissueOrgan systemsSpecific disordersDisordersPathogenesisAbnormalitiesGenetic variantsCellsCD4Variants