2015
Ethanol Upregulates NMDA Receptor Subunit Gene Expression in Human Embryonic Stem Cell-Derived Cortical Neurons
Xiang Y, Kim KY, Gelernter J, Park IH, Zhang H. Ethanol Upregulates NMDA Receptor Subunit Gene Expression in Human Embryonic Stem Cell-Derived Cortical Neurons. PLOS ONE 2015, 10: e0134907. PMID: 26266540, PMCID: PMC4534442, DOI: 10.1371/journal.pone.0134907.Peer-Reviewed Original ResearchConceptsCortical neuronsReceptor subunit gene expressionNeuron-specific biomarkerReverse transcription-quantitative polymerase chain reactionNMDA receptor subunit gene expressionChronic alcohol consumptionHuman brain cellsAlcohol-responsive genesNMDA receptor genesCalcium channel activityLive human brainQuantitative polymerase chain reactionSubunit gene expressionWithdrawal treatmentPolymerase chain reactionExpression changesEthanol exposureAlcohol abuseMultiple comparison correctionBrain cellsGene expression alterationsAlcohol consumptionNeuronal functionAlcohol metabolismNeurons
2014
Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways
Zhang H, Wang F, Xu H, Liu Y, Liu J, Zhao H, Gelernter J. Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways. Human Genetics 2014, 133: 1383-1394. PMID: 25073604, PMCID: PMC4185230, DOI: 10.1007/s00439-014-1473-x.Peer-Reviewed Original ResearchConceptsCo-expressed genesGenome-wide association studiesHumanHT-12 v4 Expression BeadChipGene modulesPostmortem prefrontal cortexGene co-expression network analysisCo-expression network analysisDAVID Bioinformatics ResourcesGene expression alterationsMetabolism-related pathwaysV4 Expression BeadChipCellular functionsTranscriptome profilesFatty acid metabolismBioinformatics resourcesEnrichment analysisExpression probesBiological pathwaysAssociation studiesAldehyde detoxificationExpression alterationsGenesMitochondrial functionBrain reward regionsAcid metabolism