2019
Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans
Yang BZ, Zhou H, Cheng Z, Kranzler HR, Gelernter J. Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans. Scientific Reports 2019, 9: 18070. PMID: 31792237, PMCID: PMC6889277, DOI: 10.1038/s41598-019-53560-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesAnalgesics, OpioidBlack or African AmericanBrainCalcium-Binding ProteinsFemaleGene Expression ProfilingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, G-Protein-CoupledReceptors, Kainic AcidSex FactorsWhite PeopleConceptsOpioid dependenceOD riskSex-different effectsSex differencesInferior olivary nucleusDSM-IV diagnosisDimorphic riskSubstantia nigraAA menOlivary nucleusFrontal cortexEuropean-American subjectsADGRV1Further studiesRiskAfrican AmericansGenetic variantsDisease enrichment analysisBrainSex interactionNominal significanceMenFirst studyPutamenLung
2018
Genome‐wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test
Zhang H, Zhou H, Lencz T, Farrer LA, Kranzler HR, Gelernter J. Genome‐wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2018, 177: 511-519. PMID: 30134085, PMCID: PMC6110090, DOI: 10.1002/ajmg.b.32642.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle nucleotide polymorphismsAssociation studiesGenome-wide significant associationUbiquitin-specific peptidase 9Top single nucleotide polymorphismsComplex trait analysisEnriched gene setsPolygenic risk score analysisCommon single nucleotide polymorphismsGWS associationsSame effect directionGene setsPopulation variationProtein degradationNongenetic factorsTrait analysisChromosome 15Genetic correlationsRisk score analysisNucleotide polymorphismsEffect directionEuropean-American subjectsGenetic factorsBrain development
2014
Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans
Arias AJ, Gelernter J, Gueorguieva R, Ralevski E, Petrakis IL. Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans. American Journal On Addictions 2014, 23: 288-293. PMID: 24724887, PMCID: PMC4600600, DOI: 10.1111/j.1521-0391.2014.12102.x.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DeterrentsAlcoholismDiagnosis, Dual (Psychiatry)DisulfiramDopamine beta-HydroxylaseDrug Therapy, CombinationFemaleGenotypeHeterozygoteHumansMaleMental DisordersMiddle AgedNaltrexoneNarcotic AntagonistsPolymorphism, Single NucleotideReceptors, Opioid, muTreatment OutcomeVeteransWhite PeopleConceptsAllele carriersHeavy drinkingCo-occurring alcohol dependenceT allele carriersAlcohol-dependent subjectsAD treatment responseTreatment of individualsPrimary outcomePharmacogenetic interactionsHigher overall rateTreatment responseAxis INaltrexoneT carriersEuropean-American subjectsOPRM1 rs1799971Favorable responseMore abstinenceAlcohol dependenceDependent subjectsDBH rs1611115DisulfiramGenotyped subjectsAbstinenceLess drinking
2013
Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans
Arias A, Gelernter J, Gueorguieva R, Ralevski E, Petrakis I. Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans. American Journal On Addictions 2013 DOI: 10.1111/j.1521-0391.2013.12102.x.Peer-Reviewed Original ResearchAllele carriersHeavy drinkingCo-occurring alcohol dependenceT allele carriersAlcohol-dependent subjectsAD treatment responseTreatment of individualsPrimary outcomePharmacogenetic interactionsHigher overall rateTreatment responseAxis INaltrexoneT carriersEuropean-American subjectsFavorable responseOPRM1 rs1799971More abstinenceAlcohol dependenceDependent subjectsDBH rs1611115DisulfiramGenotyped subjectsAbstinenceLess drinkingGenome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene
Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer L. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Molecular Psychiatry 2013, 19: 717-723. PMID: 23958962, PMCID: PMC3865158, DOI: 10.1038/mp.2013.99.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCDC2 Protein KinaseCocaineCocaine-Related DisordersCyclin-Dependent KinasesDopamine Uptake InhibitorsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotyping TechniquesHumansMaleNuclear Receptor Co-Repressor 2Paranoid DisordersPolymorphism, Single NucleotideUnited StatesWhite PeopleConceptsGenome-wide association studiesAssociation studiesAvailable GWAS dataSignificant GWAS SNPsNovel risk lociGWAS data setsSame chromosomal regionDiscovery sampleGenomes reference panelPrevious linkage studiesGWAS SNPsGWAS dataRelated traitsChromosomal regionsRisk lociRisk genesRisk variantsGenesReference panelAdditional genotypesLinkage studiesLociEuropean-American subjectsCocaine-induced paranoiaFAM53B
2010
Genetic Associations of Brain Structural Networks in Schizophrenia: A Preliminary Study
Jagannathan K, Calhoun VD, Gelernter J, Stevens MC, Liu J, Bolognani F, Windemuth A, Ruaño G, Assaf M, Pearlson GD. Genetic Associations of Brain Structural Networks in Schizophrenia: A Preliminary Study. Biological Psychiatry 2010, 68: 657-666. PMID: 20691427, PMCID: PMC2990476, DOI: 10.1016/j.biopsych.2010.06.002.Peer-Reviewed Original ResearchConceptsSpecific structural brain abnormalitiesMagnetic resonance imaging (MRI) scansSmall sample sizeHealthy control subjectsStructural brain abnormalitiesStructural magnetic resonance imaging (MRI) scansGray matter deficitsResonance imaging scansCortical gray matterNormal central nervous system developmentRisk genesCentral nervous system developmentBrain structural networksControl subjectsImaging scansBrain abnormalitiesNervous system developmentIllness markersSchizophrenia pathophysiologySchizophrenia risk genesGenetic componentTemporal lobeBrain areasEuropean-American subjectsSchizophrenia patients
2009
A sequencing‐based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls
Amin Z, Kanarek K, Krupitsky E, Walderhaug E, Ilomäki R, Blumberg H, Price LH, Bhagwagar Z, Carpenter LL, Tyrka AR, Magnusson A, Landrø NI, Zvartau E, Gelernter J, Epperson CN, Räsänen P, Siironen J, Lappalainen J. A sequencing‐based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2009, 153B: 332-335. PMID: 19455599, PMCID: PMC3580167, DOI: 10.1002/ajmg.b.30984.Peer-Reviewed Original Research
2007
Variation in GABRA2 Predicts Drinking Behavior in Project MATCH Subjects
Bauer LO, Covault J, Harel O, Das S, Gelernter J, Anton R, Kranzler HR. Variation in GABRA2 Predicts Drinking Behavior in Project MATCH Subjects. Alcohol Clinical And Experimental Research 2007, 31: 1780-1787. PMID: 17949392, PMCID: PMC3169387, DOI: 10.1111/j.1530-0277.2007.00517.x.Peer-Reviewed Original ResearchConceptsTwelve-step facilitationMotivational enhancement therapyCognitive behavioral therapyPsychosocial treatmentsSingle nucleotide polymorphismsAlcohol dependenceGABRA2 single nucleotide polymorphismsMulti-center randomized clinical trialHeavy drinkingRandomized clinical trialsLow-risk allelesPost-treatment periodPresent studyClinical trialsLower riskEuropean-American subjectsAlcoholism treatmentBehavioral therapyGABRA2 genotypeGABRA2 geneEnhancement therapyLower daily probabilityDrinking outcomesGenetic vulnerabilityPrevious studies
2006
Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence
Zhang H, Ozbay F, Lappalainen J, Kranzler HR, van Dyck CH, Charney DS, Price LH, Southwick S, Yang B, Rasmussen A, Gelernter J. Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2006, 141B: 387-393. PMID: 16649215, PMCID: PMC2567822, DOI: 10.1002/ajmg.b.30332.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlzheimer DiseaseBrain-Derived Neurotrophic FactorChromatography, High Pressure LiquidDNA Mutational AnalysisFemaleGene FrequencyGenotypeHaplotypesHumansLinkage DisequilibriumLogistic ModelsMaleMiddle AgedMood DisordersPolymorphism, Single NucleotideSchizophreniaStress Disorders, Post-TraumaticSubstance-Related DisordersConceptsPosttraumatic stress disorderAffective disordersAlzheimer's diseaseSubstance dependenceGene variantsStress disorderBDNF gene variantsNormal control subjectsLogistic regression analysisAge of subjectsBDNF variantsNeurotrophic factorControl subjectsBDNF geneBDNF SNPsG genotypeEuropean-American subjectsG alleleDrug dependenceNeuropsychiatric disordersModest associationSchizophreniaDiseaseNovel gene variantsDisorders
2004
Allelic and haplotypic association of GABRA2 with alcohol dependence
Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR. Allelic and haplotypic association of GABRA2 with alcohol dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 129B: 104-109. PMID: 15274050, DOI: 10.1002/ajmg.b.30091.Peer-Reviewed Original ResearchConceptsAlcohol-dependent subjectsAlcohol dependenceSingle nucleotide polymorphismsMajor depressive episodeGABAA receptor subunitsSubstance use disordersHaplotypic associationsEvidence of associationSerious morbidityOpioid dependenceAlpha 2 subunitDepressive episodePrevalent disorderUse disordersEuropean-American subjectsNeurotransmitter receptorsControl groupDrug dependenceReceptor subunitsCommon haplotypeGABRA2 geneBehavioral effectsImportant mediatorAssociationSubjectsCentral Serotonin Transporter Availability Measured With 123I-CIT SPECT in Relation to Serotonin Transporter Genotype
van Dyck CH, Malison RT, Staley JK, Jacobsen LK, Seibyl JP, Laruelle M, Baldwin RM, Innis RB, Gelernter J. Central Serotonin Transporter Availability Measured With 123I-CIT SPECT in Relation to Serotonin Transporter Genotype. American Journal Of Psychiatry 2004, 161: 525-531. PMID: 14992979, DOI: 10.1176/appi.ajp.161.3.525.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAllelesBrainBrain MappingCarrier ProteinsCocaineFemaleGene FrequencyGenotypeHumansIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsPolymorphism, GeneticPromoter Regions, GeneticReference ValuesSerotonin Plasma Membrane Transport ProteinsTandem Repeat SequencesTomography, Emission-Computed, Single-PhotonConceptsSERT availabilitySerotonin transporter proteinEuropean-American subjectsSERT levelsCentral serotonin transporter availabilitySLC6A4 promoter polymorphismSerotonin transporter availabilitySingle photon emissionEffect of ageLong alleleSerotonin transmissionBrain uptakeLong homozygotesAmerican subjectsTransporter availabilityPromoter polymorphismSerotonin transporter genotypeClinical phenotypeTomography scanningNeuropsychiatric diseasesNonneural cellsFunctional polymorphismsSLC6A4 genotypeNonsignificant tendencyTransporter genotypeNOTCH4 gene haplotype is associated with schizophrenia in African Americans
Luo X, Klempan TA, Lappalainen J, Rosenheck RA, Charney DS, Erdos J, van Kammen DP, Kranzler HR, Kennedy JL, Gelernter J. NOTCH4 gene haplotype is associated with schizophrenia in African Americans. Biological Psychiatry 2004, 55: 112-117. PMID: 14732589, DOI: 10.1016/s0006-3223(03)00588-2.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanChi-Square DistributionCysteineDiagnostic and Statistical Manual of Mental DisordersFemaleGene FrequencyGenotypeGlycineHaplotypesHumansLinkage DisequilibriumMalePolymerase Chain ReactionPolymorphism, Single NucleotideProto-Oncogene ProteinsReceptor, Notch4Receptors, Cell SurfaceReceptors, NotchSchizophreniaThreonineConceptsHealthy control subjectsControl subjectsSingle nucleotide polymorphismsExact testSchizophrenia patientsAfrican AmericansFisher's exact testNOTCH4 locusChi-square testComparison of alleleEuropean-American subjectsPositive linkage disequilibriumAA subjectsPatientsSchizophreniaSpecific markersHaplotype frequenciesT associatesLinkage disequilibriumEA subjectsNOTCH4 geneSubjectsGene haplotypesAmerican subjectsNucleotide polymorphisms
2003
CALCYON gene variation, schizophrenia, and cocaine dependence
Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J. CALCYON gene variation, schizophrenia, and cocaine dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 125B: 25-30. PMID: 14755439, DOI: 10.1002/ajmg.b.20092.Peer-Reviewed Original ResearchConceptsCocaine dependenceSingle nucleotide polymorphismsExact testEA subjectsFisher's exact testSubstance use disordersCalcyon geneDopamine receptor-interacting proteinsComparison of alleleUse disordersEuropean-American subjectsControl groupAA subjectsSchizophreniaReceptor-interacting proteinHaplotype frequenciesPotential roleSpecific polymorphismsMotor controlGene variationSame haplotype blockGenetic variantsSubjectsNucleotide polymorphismsLinkage disequilibrium
1998
Serotonin Transporter Protein Gene Polymorphism and Personality Measures in African American and European American Subjects
Gelernter J, Kranzler H, Coccaro EF, Siever LJ, New AS. Serotonin Transporter Protein Gene Polymorphism and Personality Measures in African American and European American Subjects. American Journal Of Psychiatry 1998, 155: 1332-1338. PMID: 9766763, DOI: 10.1176/ajp.155.10.1332.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack PeopleCarrier ProteinsFemaleGene FrequencyGenotypeHumansIntronsMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsPersonalityPersonality DisordersPolymorphism, GeneticPromoter Regions, GeneticSerotoninSerotonin Plasma Membrane Transport ProteinsSubstance-Related DisordersWhite PeopleConceptsOverall negative findingsSLC6A4 promoter polymorphismNormal comparison subjectsPsychiatric diagnostic groupsProtein gene polymorphismsAmerican subjectsSynaptic inactivationComparison subjectsPromoter polymorphismPsychiatric diagnosisEuropean-American subjectsGene polymorphismsNeuroticism scoresDiagnostic groupsDemographic featuresNegative findingsHarm avoidanceNeurotransmitter serotoninSubstance dependenceSerotonin transporterPersonality disorderSLC6A4 polymorphismsDemographic factorsPresent findingsPromoter regionDRD2 Allele Frequencies and Linkage Disequilibria, Including the -141CIns/DelPromoter Polymorphism, in European-American, African-American, and Japanese Subjects
Gelernter J, Kranzler H, Cubells JF, Ichinose H, Nagatsu T. DRD2 Allele Frequencies and Linkage Disequilibria, Including the -141CIns/DelPromoter Polymorphism, in European-American, African-American, and Japanese Subjects. Genomics 1998, 51: 21-26. PMID: 9693029, DOI: 10.1006/geno.1998.5264.Peer-Reviewed Original ResearchConceptsLinkage disequilibriumFunctional variantsSignificant linkage disequilibriumMutational analysis studiesFirst intronKb 5Linkage disequilibriaFrequencies of haplotypesPopulation stratificationGenetic associationDrd2 promoterPhysiological basisAllele frequenciesPhysiological relationshipGenesReceptor allelesEuropean-American subjectsD2 dopamine receptor (DRD2) allelesDisequilibriumBehavioral phenotypesPhenotypeFunctional meaningEuropean originVariantsAmerican population