2013
Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol Dependence
Han S, Yang BZ, Kranzler HR, Liu X, Zhao H, Farrer LA, Boerwinkle E, Potash JB, Gelernter J. Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol Dependence. American Journal Of Human Genetics 2013, 93: 1027-1034. PMID: 24268660, PMCID: PMC3853414, DOI: 10.1016/j.ajhg.2013.10.021.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesHuman protein interaction networkGene subnetworksProtein interaction networksIntegrating Genome-Wide Association StudyInteraction networksHuman complex disordersSubnetworks of genesGWAS data setsFunctional enrichment analysisAD risk genesEnrichment analysisProtein productsAssociation studiesSignificant genetic contributionGenesGenetics of AlcoholismStudy of AddictionGenetic contributionGeneticsComplex disorderAD etiologyCation transportImportant cluesEuropean descentAssociation of Gamma-Aminobutyric Acid A Receptor α2 Gene (GABRA2) with Alcohol Use Disorder
Li D, Sulovari A, Cheng C, Zhao H, Kranzler HR, Gelernter J. Association of Gamma-Aminobutyric Acid A Receptor α2 Gene (GABRA2) with Alcohol Use Disorder. Neuropsychopharmacology 2013, 39: 907-918. PMID: 24136292, PMCID: PMC3924525, DOI: 10.1038/npp.2013.291.Peer-Reviewed Original ResearchConceptsReceptor geneGABA receptor genesGABAA receptor genesCandidate gene association studiesSAGE data setsBonferroni-corrected thresholdGene association studiesSingle nucleotide polymorphismsAssociation studiesGenotype dataStudy of AddictionGamma-aminobutyric acidMammalian brainGenesComplex disorderGABRA2 single nucleotide polymorphismsSubstance dependenceMajor inhibitory neurotransmitterGeneticsInhibitory neurotransmitterVariantsGABA receptorsSignificant associationSubstance abuseMethamphetamine dependence
2012
ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.
Chen XD, Xiong DH, Yang TL, Pei YF, Guo YF, Li J, Yang F, Pan F, Tan LJ, Yan H, Liu XG, Lei SF, Li X, Ning LL, Zhu XZ, Levy S, Kranzler HR, Farrer LA, Gelernter J, Recker RR, Deng HW. ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. Chinese Medical Journal 2012, 125: 1127-34. PMID: 22613542, PMCID: PMC4174677.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAlcohol-related phenotypesAssociation studiesUnrelated Caucasian subjectsGenome-wide significance levelAffymetrix 500K SNP arrayK SNP arrayNovel risk genesCaucasian nuclear familiesGWAS technologySuggestive statistical evidenceSNP arrayANKRD7GenesRisk genesSusceptibility genesUnrelated Chinese HansSusceptibility allelesCertain haplotypesComplex disorderReplication sampleEnvironmental factorsUnrelated CaucasiansPhenotypeChinese Han
2008
Substance dependence low-density whole genome association study in two distinct American populations
Yu Y, Kranzler HR, Panhuysen C, Weiss RD, Poling J, Farrer LA, Gelernter J. Substance dependence low-density whole genome association study in two distinct American populations. Human Genetics 2008, 123: 495. PMID: 18438686, PMCID: PMC3428017, DOI: 10.1007/s00439-008-0501-0.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphism (SNP) markersWhole-genome association studiesFuture candidate gene studiesGenome association studiesCandidate gene studiesPotential biological relevancePolymorphism markersGenetic basisAssociation studiesGenetic markersHigh heritabilityGene studiesCocaine-induced paranoiaBiological relevanceGenesComplex disorderNew hypothesisFamilyAmerican populationGeneticsHeritabilityMarkers