2019
Alcohol-responsive genes identified in human iPSC-derived neural cultures
Jensen KP, Lieberman R, Kranzler HR, Gelernter J, Clinton K, Covault J. Alcohol-responsive genes identified in human iPSC-derived neural cultures. Translational Psychiatry 2019, 9: 96. PMID: 30862775, PMCID: PMC6414668, DOI: 10.1038/s41398-019-0426-5.Peer-Reviewed Original ResearchConceptsAlcohol-responsive genesGene expressionGene regulatory effectsTotal RNA sequencingCo-expressed genesNeural cell culturesCholesterol biosynthesis pathwayPrimary neural tissueCorrelation network analysisHuman-induced pluripotent stem cellsPluripotent stem cellsBiosynthesis pathwayCell culturesResponsive genesRNA sequencingNotch signalingEnrichment analysisMolecular mechanismsCell cycleAlcohol exposureGenesCell culture modelGenetic effectsCholesterol homeostasisStem cells
2014
Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways
Zhang H, Wang F, Xu H, Liu Y, Liu J, Zhao H, Gelernter J. Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways. Human Genetics 2014, 133: 1383-1394. PMID: 25073604, PMCID: PMC4185230, DOI: 10.1007/s00439-014-1473-x.Peer-Reviewed Original ResearchConceptsCo-expressed genesGenome-wide association studiesHumanHT-12 v4 Expression BeadChipGene modulesPostmortem prefrontal cortexGene co-expression network analysisCo-expression network analysisDAVID Bioinformatics ResourcesGene expression alterationsMetabolism-related pathwaysV4 Expression BeadChipCellular functionsTranscriptome profilesFatty acid metabolismBioinformatics resourcesEnrichment analysisExpression probesBiological pathwaysAssociation studiesAldehyde detoxificationExpression alterationsGenesMitochondrial functionBrain reward regionsAcid metabolism