2020
Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program
Levey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF, Stein M. Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. American Journal Of Psychiatry 2020, 177: 223-232. PMID: 31906708, PMCID: PMC7869502, DOI: 10.1176/appi.ajp.2019.19030256.Peer-Reviewed Original ResearchConceptsNovel genome-wide significant associationsGene expressionGenome-wide significant signalsGenome-wide significant associationMillion Veteran ProgramWide association studyGenetic risk lociSignificant genetic correlationsGenetic risk mechanismsGenetic architectureGlobal regulatorChromosome 3Risk lociChromosome 6Chromosome 7Association studiesLargest GWASLarge biobanksGlobal regulationGenetic correlationsContinuous traitsVeteran ProgramGWASsLociPrevious GWASs
2008
Quantitative Trait Locus Analysis Identifies Rat Genomic Regions Related to Amphetamine-Induced Locomotion and Gαi3 Levels in Nucleus Accumbens
Potenza MN, Brodkin ES, Yang BZ, Birnbaum SG, Nestler EJ, Gelernter J. Quantitative Trait Locus Analysis Identifies Rat Genomic Regions Related to Amphetamine-Induced Locomotion and Gαi3 Levels in Nucleus Accumbens. Neuropsychopharmacology 2008, 33: 2735-2746. PMID: 18216777, PMCID: PMC2818767, DOI: 10.1038/sj.npp.1301667.Peer-Reviewed Original ResearchConceptsQuantitative trait lociRobust quantitative trait lociGenomic regionsChromosome 2Quantitative trait locus (QTL) analysisG protein levelsCommon genetic mechanismQTL patternsTrait lociRat genomic regionsGenetic mechanismsChromosome 3Locus analysisChromosome 13Genetic factorsGαi3LociAmphetamine-Induced LocomotionBetter understandingLocomotionRegionAnimal modelsSignificant implicationsLevelsNovelty-induced locomotion
2001
Linkage genome scan for loci predisposing to panic disorder or agoraphobia
Gelernter J, Bonvicini K, Page G, Woods S, Goddard A, Kruger S, Pauls D, Goodson S. Linkage genome scan for loci predisposing to panic disorder or agoraphobia. American Journal Of Medical Genetics 2001, 105: 548-557. PMID: 11496373, DOI: 10.1002/ajmg.1496.Peer-Reviewed Original ResearchMeSH KeywordsAgoraphobiaChromosome MappingChromosomes, Human, Pair 1Chromosomes, Human, Pair 11Chromosomes, Human, Pair 14Chromosomes, Human, Pair 3Chromosomes, Human, Pair 4Family HealthFemaleGenetic Predisposition to DiseaseGenome, HumanHumansLod ScoreMaleMicrosatellite RepeatsPanic DisorderPedigreeConceptsLinkage genome scanGenome scanChromosome 3LOD scoreSuggestive linkagePrevious genome scanComplex traitsGenomic regionsHeritable anxiety disordersGenetic lociMultipoint LOD scoreCandidate genesRisk lociChromosome 1Chromosome 11pSusceptibility lociLociStatistical supportLinkage resultsNPL analysisPotential lociNPL scoreAmerican pedigreesSingle familyPotential linkage