C‐terminal phosphorylation of latrophilin‐1/ADGRL1 affects the interaction between its fragments
Rahman M, Manser C, Benlaouer O, Suckling J, Blackburn J, Silva J, Ushkaryov Y. C‐terminal phosphorylation of latrophilin‐1/ADGRL1 affects the interaction between its fragments. Annals Of The New York Academy Of Sciences 2019, 1456: 122-143. PMID: 31553068, DOI: 10.1111/nyas.14242.Peer-Reviewed Original ResearchConceptsN-terminal fragmentG protein-coupled receptorsC-terminal fragmentLatrophilin-1Protein-coupled receptorsAdhesion G protein-coupled receptorsProtein tyrosine phosphatase σG protein-mediated signalingProtein-mediated signalingPhosphorylated C-terminal fragmentsTerminal phosphorylationIndependent proteinsPlasma membraneSeparate proteinsΑ-latrotoxinAffinity columnProteinEndocrine cellsFragmentsHigh affinityLow affinityMultiple sitesCopurifiesDephosphorylationComplexes