2019
C‐terminal phosphorylation of latrophilin‐1/ADGRL1 affects the interaction between its fragments
Rahman M, Manser C, Benlaouer O, Suckling J, Blackburn J, Silva J, Ushkaryov Y. C‐terminal phosphorylation of latrophilin‐1/ADGRL1 affects the interaction between its fragments. Annals Of The New York Academy Of Sciences 2019, 1456: 122-143. PMID: 31553068, DOI: 10.1111/nyas.14242.Peer-Reviewed Original ResearchConceptsN-terminal fragmentG protein-coupled receptorsC-terminal fragmentLatrophilin-1Protein-coupled receptorsAdhesion G protein-coupled receptorsProtein tyrosine phosphatase σG protein-mediated signalingProtein-mediated signalingPhosphorylated C-terminal fragmentsTerminal phosphorylationIndependent proteinsPlasma membraneSeparate proteinsΑ-latrotoxinAffinity columnProteinEndocrine cellsFragmentsHigh affinityLow affinityMultiple sitesCopurifiesDephosphorylationComplexes
2018
Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones
Vysokov NV, Silva JP, Lelianova VG, Suckling J, Cassidy J, Blackburn JK, Yankova N, Djamgoz MB, Kozlov SV, Tonevitsky AG, Ushkaryov YA. Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones. ELife 2018, 7: e37935. PMID: 30457553, PMCID: PMC6245728, DOI: 10.7554/elife.37935.Peer-Reviewed Original ResearchConceptsLatrophilin-1Axonal growth conesAxonal attractionAdhesion G protein-coupled receptorsPostsynaptic transmembrane proteinsG protein-coupled receptorsGrowth conesTrans-synaptic interactionsGrowth cone steeringRegulated proteolysisTransmembrane proteinDownstream signalingAxonal pathfindingNeuronal developmentEnhanced exocytosisNovel mechanismSynapse formationNeurite outgrowthTeneurinsIntercellular spacesCytosolic calciumStable gradientSynaptogenesisExocytosisSignaling