Studies in humans and mice reveal a critical role for CCR2 in trafficking of pDCs during infection with SARS-CoV-2
Zhang H, Lu X, Garner D, Parween F, Singh S, Majumdar S, Weaver J, Stein S, Lesho P, Damcott C, Lutfi F, Petrick K, Rock P, Chertow D, Kelsall B, Murphy P, Dahiya S, Hardy N, Farber J. Studies in humans and mice reveal a critical role for CCR2 in trafficking of pDCs during infection with SARS-CoV-2. The Journal Of Immunology 2023, 210: 143.04-143.04. DOI: 10.4049/jimmunol.210.supp.143.04.Peer-Reviewed Original ResearchMAIT cellsSARS-CoV-2Chemokine receptorsCCR2-deficient miceHospitalized COVID-19 patientsCOVID-19 pathogenesisBlood pDCCOVID-19 patientsReporter miceAffecting disease severityCCR2 ligandsCCR2III interferonsBlood leukocytesType 1ChemokinesDisease severityIncreased mortalityBlood cellsReceptorsAbsolute numberLeukocyte extravasationLungTransendothelial migrationBlood