2023
Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury
Benson C, Olson K, Patwa S, Kauer S, King J, Waxman S, Tan A. Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury. Journal Of Neuroscience 2023, 44: e1670222023. PMID: 37963762, PMCID: PMC10851682, DOI: 10.1523/jneurosci.1670-22.2023.Peer-Reviewed Original ResearchConceptsSpinal cord injuryRate-dependent depressionΑ-motor neuronsGlutamate transporter 1Dendritic spine dysgenesisCord injurySpine dysgenesisDevelopment of SCIMild contusion spinal cord injuryAstrocytic glutamate transporter 1Glial-specific glutamate transporterContusion spinal cord injuryTransporter 1Development of hyperreflexiaMonosynaptic H-reflexDendritic spine densityPre-injury levelSpinal reflex circuitsVentral spinal cordReflex hyperexcitabilityHyperexcitability disordersFunctional recoveryGlutamate clearanceH-reflexVentral horn
2021
Sniff-synchronized, gradient-guided olfactory search by freely moving mice
Findley T, Wyrick D, Cramer J, Brown M, Holcomb B, Attey R, Yeh D, Monasevitch E, Nouboussi N, Cullen I, Songco J, King J, Ahmadian Y, Smear M. Sniff-synchronized, gradient-guided olfactory search by freely moving mice. ELife 2021, 10: e58523. PMID: 33942713, PMCID: PMC8169121, DOI: 10.7554/elife.58523.Peer-Reviewed Original ResearchConceptsInter-trial intervalMachine learning methodsInvestigating motifsIndividual motifsSniff cycleStereo olfactionMotifOdor targetsNeural mechanismsLearning methodsOdor gradientsOlfactory searchTask performanceMotile organismsNose movementSharp partsMotion trajectoryActive sensing movementsSensorimotor strategiesSensing movementsGradient sensingGradient cuesFast breathingAirborne odorantsBehavioral states