2018
Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats
Dong H, Keegan JM, Hong E, Gallardo C, Montalvo-Ortiz J, Wang B, Rice KC, Csernansky J. Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats. Psychoneuroendocrinology 2018, 90: 92-101. PMID: 29477954, PMCID: PMC5864558, DOI: 10.1016/j.psyneuen.2018.02.013.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnxietyBehaviorBehavior, AnimalCorticotropin-Releasing HormoneDepressionDisease Models, AnimalFemaleHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemPyrimidinesPyrrolesRatsRats, Sprague-DawleyReceptors, Corticotropin-Releasing HormoneStress, PsychologicalSynapsesConceptsStress-induced behavioral changesStress-induced anxietyAnxiety-related behaviorMemory deficitsChronic stressSynapse lossCRF1 antagonistsFactor receptor 1 antagonistCortical dendritic spinesHPA axis dysfunctionBody weight lossReceptor 1 antagonistMonths of ageSubset of animalsBehavioral changesFactor receptor 1Axis dysfunctionAged brainAged ratsPotential therapyDendritic spinesAnimal modelsCorticosterone levelsAlzheimer's diseaseReceptor 1
2016
The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect
Montalvo-Ortiz JL, Bordner KA, Carlyle BC, Gelernter J, Simen AA, Kaufman J. The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect. Behavioural Brain Research 2016, 315: 71-74. PMID: 27506655, PMCID: PMC5396458, DOI: 10.1016/j.bbr.2016.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDepressionDisease Models, AnimalGene Expression RegulationInhibitor of Differentiation ProteinsMaleMaternal DeprivationMaze LearningMiceMice, Inbred C57BLMice, Inbred DBAMicroarray AnalysisNerve Tissue ProteinsNeuronal PlasticityPrefrontal CortexReceptors, N-Methyl-D-AspartateRNA, MessengerStress, PsychologicalSwimmingConceptsTubulin Polymerization Promoting ProteinRole of genesGene expression dataEpigenetic changesGene expressionPhenotype dataExpression dataPrefrontal cortex tissueGenesSecondary analysisMedial prefrontal cortex (mPFC) tissueGlutamate NMDA receptorsAdult male miceId-3Early life stressPhenotypeSwimming testMale miceNMDA receptorsDepression riskMaternal separationMouse modelDepressive phenotypeBrain circuitryBehavioral differences