2023
Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer’s disease
Rodriguez G, Fisher D, McClarty B, Montalvo-Ortiz J, Cui Q, Chan C, Dong H. Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer’s disease. Frontiers In Psychiatry 2023, 13: 1020831. PMID: 36684015, PMCID: PMC9852991, DOI: 10.3389/fpsyt.2022.1020831.Peer-Reviewed Original ResearchMotor side effectsSevere neuropsychiatric symptomsAged miceSide effectsHDAC inhibitorsNeuropsychiatric symptomsDementia patientsHistone deacetylase inhibitor valproic acidAtypical antipsychotic risperidoneTypical antipsychotic haloperidolAntipsychotic drug targetsGreater side effectsInhibitor valproic acidHistone deacetylase inhibitorsAge-related sensitivityEpigenetic alterationsAtypical antipsychoticsD2R expressionAntipsychotic haloperidolLabel useAntipsychotic risperidoneAntipsychotic drugsMouse modelValproic acidClinical practice
2018
Methylation in OTX2 and related genes, maltreatment, and depression in children
Kaufman J, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff R, O’Loughlin K, Holbrook H, Garavan H, Kearney C, Yang BZ, Zhao H, Peña C, Nestler EJ, Lee RS, Mostofsky S, Gelernter J, Hudziak J. Methylation in OTX2 and related genes, maltreatment, and depression in children. Neuropsychopharmacology 2018, 43: 2204-2211. PMID: 30089883, PMCID: PMC6135753, DOI: 10.1038/s41386-018-0157-y.Peer-Reviewed Original ResearchConceptsMouse modelStress-related depressive disordersResting-state functional connectivity dataResting-state functional MRI dataDepressive-like behaviorEarly life stressSubset of childrenDNA specimensMedial frontal cortexPeripheral markersMeasures of depressionHomeobox 2 geneSubcallosal gyrusFunctional connectivity dataDepressive disorderFrontal cortexChild adversityMultiple molecular toolsFunctional MRI dataFrontal poleLarger studyFunctional connectivitySaliva samplesBilateral regionsUnbiased transcriptomics
2016
The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect
Montalvo-Ortiz JL, Bordner KA, Carlyle BC, Gelernter J, Simen AA, Kaufman J. The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect. Behavioural Brain Research 2016, 315: 71-74. PMID: 27506655, PMCID: PMC5396458, DOI: 10.1016/j.bbr.2016.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDepressionDisease Models, AnimalGene Expression RegulationInhibitor of Differentiation ProteinsMaleMaternal DeprivationMaze LearningMiceMice, Inbred C57BLMice, Inbred DBAMicroarray AnalysisNerve Tissue ProteinsNeuronal PlasticityPrefrontal CortexReceptors, N-Methyl-D-AspartateRNA, MessengerStress, PsychologicalSwimmingConceptsTubulin Polymerization Promoting ProteinRole of genesGene expression dataEpigenetic changesGene expressionPhenotype dataExpression dataPrefrontal cortex tissueGenesSecondary analysisMedial prefrontal cortex (mPFC) tissueGlutamate NMDA receptorsAdult male miceId-3Early life stressPhenotypeSwimming testMale miceNMDA receptorsDepression riskMaternal separationMouse modelDepressive phenotypeBrain circuitryBehavioral differences
2014
Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice
Dong H, Wang S, Zeng Z, Li F, Montalvo-Ortiz J, Tucker C, Akhtar S, Shi J, Meltzer HY, Rice KC, Csernansky JG. Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice. Psychopharmacology 2014, 231: 4711-4722. PMID: 24862368, PMCID: PMC4233002, DOI: 10.1007/s00213-014-3629-8.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsCorticotropin-Releasing HormoneCyclic AMPCyclic AMP-Dependent Protein KinasesDisease Models, AnimalHippocampusMaleMemoryMiceMice, TransgenicNeuronsPlaque, AmyloidPyrimidinesPyrrolesReceptors, Corticotropin-Releasing HormoneSignal TransductionConceptsAβ1-42 levelsCorticotrophin-releasing factorReceptor 1 antagonistPlaque depositionCRF1 antagonistsMouse modelDays of ageAlzheimer's diseaseMouse pupsIsolation stressCRF receptor 1 antagonistFactor receptor 1 antagonistAdministration of antalarminExogenous CRF administrationCultured primary hippocampal neuronsDaily intraperitoneal injectionsIncubation of neuronsCohort of micePlasma corticosterone levelsPrimary hippocampal neuronsMonths of ageCRF administrationAβ levelsIntraperitoneal injectionHippocampal neurons
2012
Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease
Dong H, Murphy KM, Meng L, Montalvo-Ortiz J, Zeng Z, Kolber BJ, Zhang S, Muglia LJ, Csernansky JG. Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease. Journal Of Alzheimer's Disease 2012, 28: 579-592. PMID: 22045495, PMCID: PMC3494090, DOI: 10.3233/jad-2011-111328.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnalysis of VarianceAnimalsAnxietyBody WeightCalcium-Calmodulin-Dependent Protein Kinase Type 2Cognition DisordersConditioning, PsychologicalCorticosteroneCorticotropin-Releasing HormoneDark AdaptationDendritic SpinesDisease Models, AnimalDoxycyclineEnzyme-Linked Immunosorbent AssayExploratory BehaviorFearGene Expression RegulationHumansMiceMice, TransgenicNeuronsPlaque, AmyloidProsencephalonReceptors, Corticotropin-Releasing HormoneSilver StainingTubulinConceptsCorticotrophin-releasing factorTransgenic mouse modelTriple transgenic mouse modelTT miceMouse modelMonths of ageAlzheimer's diseaseExpression of CRFChronic stressHuman amyloid-β protein precursorNovel transgenic mouse modelDendritic spine densityAmyloid-β protein precursorAnxiety-like behaviorAβPP genePyramidal neuronsSpine densityAmyloid depositionAmyloid metabolismCRF expressionFrontal cortexBehavioral deficitsDendritic branchingCognitive declineMice