The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys
Lawrence M, Redmond D, Elsworth J, Taylor J, Roth R. The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys. Life Sciences 1991, 49: pl229-pl234. PMID: 1836030, DOI: 10.1016/0024-3205(91)90299-q.Peer-Reviewed Original ResearchConceptsSCH 23390African green monkeysD1 antagonistHealthy African green monkeysGreen monkeysParkinsonian side effectsD1 receptor antagonistPoverty of movementSigns of parkinsonismSelective D1 antagonistFull D1 agonistParkinsonian signsReceptor antagonistD1 agonistD1 receptorsSystemic administrationParkinson's diseasePsychiatric disordersSide effectsMotor changesClinical useParkinsonismAntagonistBlink rateMonkeysCocaethylene: A neuropharmacologically active metabolite assciated with concurrent cocaine-ethanol ingestion
Jatlow P, Elsworth JD, Bradberry CW, Winger G, Taylor JR, Russell R, Roth RH. Cocaethylene: A neuropharmacologically active metabolite assciated with concurrent cocaine-ethanol ingestion. Life Sciences 1991, 48: 1787-1794. PMID: 2020260, DOI: 10.1016/0024-3205(91)90217-y.Peer-Reviewed Original ResearchConceptsDopamine uptake systemEffects of cocaineExtracellular dopamine concentrationBlood of individualsSelf-administration studiesInhibition of bindingEthanol abuseSystemic administrationNucleus accumbensDopamine reuptakeLocomotor activityActive metaboliteDopamine concentrationsBehavioral effectsCocaineEffects of ECRatsVivo formationEquipotentInhibitionSame extent