2011
Induction of Persistent Depressive-Like Behavior by Corticosterone
Gourley S, Taylor J. Induction of Persistent Depressive-Like Behavior by Corticosterone. Neuromethods 2011, 63: 251-265. DOI: 10.1007/978-1-61779-313-4_16.Peer-Reviewed Original ResearchChronic CORT exposureDepressive-like behaviorCORT exposureChronic depressive-like stateChronic mild stress modelStress-related mood disordersChronic antidepressant treatmentSerum CORT levelsNeurobiology of depressionDepressive-like stateChronic oral exposureCharacteristics of depressionAntidepressant efficacyAntidepressant treatmentAdrenal hormonesOral exposureMood disordersFeelings of anhedoniaLocomotor activityNaïve rodentsCORT levelsCorticosteroneDepressionBehavioral consequencesExposure
2009
Recapitulation and Reversal of a Persistent Depression‐like Syndrome in Rodents
Gourley SL, Taylor JR. Recapitulation and Reversal of a Persistent Depression‐like Syndrome in Rodents. Current Protocols In Neuroscience 2009, 49: 9.32.1-9.32.11. PMID: 19802817, PMCID: PMC2774936, DOI: 10.1002/0471142301.ns0932s49.Peer-Reviewed Original ResearchConceptsCORT exposureChronic mild stress modelChronic antidepressant treatmentChronic CORT exposureHelplessness-like behaviorDepressive-like stateNeurobiology of depressionDepression-like syndromeChronic oral exposureAntidepressant efficacyAntidepressant treatmentAdrenal hormonesOral exposureNucleus accumbensMouse modelFeelings of anhedoniaNaïve rodentsMultiple biological functionsMolecular targetsCAMP response elementDepressionFactor activityCorticosteroneExposure periodExposure
2008
Corticosterone Regulates pERK1/2 Map Kinase in a Chronic Depression Model
Gourley SL, Wu FJ, Taylor JR. Corticosterone Regulates pERK1/2 Map Kinase in a Chronic Depression Model. Annals Of The New York Academy Of Sciences 2008, 1148: 509-514. PMID: 19120149, PMCID: PMC3657205, DOI: 10.1196/annals.1410.076.Peer-Reviewed Original ResearchConceptsDepression modelCA1/CA3Chronic depression modelPrefrontal cortical targetsExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Antidepressant efficacyDentate gyrusCorticosterone exposureCortical targetsReceptor typesKinase 1/2Motivated behaviorNovel roleIntracellular signalingPERK1/2MAP kinaseTranscriptional activityNeurotrophinsHippocampusCorticosteroneCA3GyrusMiceInsultAcute Hippocampal Brain-Derived Neurotrophic Factor Restores Motivational and Forced Swim Performance After Corticosterone
Gourley SL, Kiraly DD, Howell JL, Olausson P, Taylor JR. Acute Hippocampal Brain-Derived Neurotrophic Factor Restores Motivational and Forced Swim Performance After Corticosterone. Biological Psychiatry 2008, 64: 884-890. PMID: 18675955, PMCID: PMC2633780, DOI: 10.1016/j.biopsych.2008.06.016.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorHippocampal brain-derived neurotrophic factorAntidepressant treatmentCORT exposureCORT secretionAppetitive instrumental behaviorChronic antidepressant treatmentDepressive-like stateNeurobiology of depressionHippocampal BDNF expressionAdult male miceAnhedonic-like behaviorResponse Element-Binding Protein PhosphorylationCAMP response element-binding protein (CREB) phosphorylationProgressive ratio taskElement-Binding Protein PhosphorylationADT efficacyCORT modelAntidepressant efficacyBDNF expressionHippocampal brainNeurotrophic factorSwim testCorticosterone exposureMale mice
2007
Regionally Specific Regulation of ERK MAP Kinase in a Model of Antidepressant-Sensitive Chronic Depression
Gourley SL, Wu FJ, Kiraly DD, Ploski JE, Kedves AT, Duman RS, Taylor JR. Regionally Specific Regulation of ERK MAP Kinase in a Model of Antidepressant-Sensitive Chronic Depression. Biological Psychiatry 2007, 63: 353-359. PMID: 17889834, PMCID: PMC2277331, DOI: 10.1016/j.biopsych.2007.07.016.Peer-Reviewed Original ResearchMeSH KeywordsAmitriptylineAnimalsAntidepressive Agents, TricyclicAnti-Inflammatory AgentsChronic DiseaseConditioning, OperantCorticosteroneCREB-Binding ProteinDentate GyrusDepressive Disorder, MajorDisease Models, AnimalEndoplasmic Reticulum Chaperone BiPExtracellular Signal-Regulated MAP KinasesFluoxetineHeat-Shock ProteinsHippocampusLocomotionMiceMice, Inbred C57BLMolecular ChaperonesMotivationSelective Serotonin Reuptake InhibitorsConceptsAntidepressant efficacyChronic corticosteroneDentate gyrusChronic depressionCA1/CA3Depression-like behaviorExtracellular signal-regulated kinase 1/2Response element-binding proteinSignal-regulated kinase 1/2Amitriptyline treatmentGlucocorticoid exposureADT treatmentNaive rodentsBehavioral despairLong-term consequencesTail suspensionElement-binding proteinCyclic adenosine monophosphateBiochemical measuresERK MAP kinasePrefrontal cortexHeat shock proteinsOperant conditioning taskCommon mediatorPERK1/2