2015
Obsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children
Alvarenga PG, Cesar RC, Leckman JF, Moriyama TS, Torres AR, Bloch MH, Coughlin CG, Hoexter MQ, Manfro GG, Polanczyk GV, Miguel EC, do Rosario MC. Obsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children. Journal Of Psychiatric Research 2015, 62: 108-114. PMID: 25702286, DOI: 10.1016/j.jpsychires.2015.01.018.Peer-Reviewed Original ResearchConceptsSchool-aged childrenPsychiatric symptomsFamily History ScreenAdditional clinical factorsSymptom dimensionsCommunity-based sampleObsessive-compulsive symptom dimensionsClinical factorsObsessive-compulsive disorderPsychiatric comorbidityClinical impairmentSchool impairmentCross-sectional sampleAge 6Clinical samplesFamilial aggregationBiological mothersChildrenBiological relativesSymptomsPrevalenceAge distributionImpairmentNon-clinical samplePresent study
2014
Gender and Injuries Predict Stimulant Medication Use
Dalsgaard S, Leckman JF, Nielsen HS, Simonsen M. Gender and Injuries Predict Stimulant Medication Use. Journal Of Child And Adolescent Psychopharmacology 2014, 24: 253-259. PMID: 24813570, PMCID: PMC4064734, DOI: 10.1089/cap.2013.0101.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildChild Development Disorders, PervasiveCraniocerebral TraumaFemaleFollow-Up StudiesHumansMaleMental DisordersPractice Patterns, Physicians'Prospective StudiesSeverity of Illness IndexSex FactorsWounds and InjuriesConceptsAttention-deficit/hyperactivity disorderStimulant treatmentNumber of injuriesADHD medicationPsychiatric disordersStimulant medicationAutism spectrum disorderFirst prospective studyGroup of patientsPopulation-based studyYears of ageEarly life predictorsStimulant medication useMedication useGroup of childrenProspective studyPharmacological treatmentHead injuryNational cohortDrug prescriptionsMale genderPsychiatric diagnosisMedicationsNational registersInjury
2012
Systematic review: Pharmacological treatment of tic disorders – Efficacy of antipsychotic and alpha-2 adrenergic agonist agents
Weisman H, Qureshi IA, Leckman JF, Scahill L, Bloch MH. Systematic review: Pharmacological treatment of tic disorders – Efficacy of antipsychotic and alpha-2 adrenergic agonist agents. Neuroscience & Biobehavioral Reviews 2012, 37: 1162-1171. PMID: 23099282, PMCID: PMC3674207, DOI: 10.1016/j.neubiorev.2012.09.008.Peer-Reviewed Original Research
2011
Poor fine‐motor and visuospatial skills predict persistence of pediatric‐onset obsessive‐compulsive disorder into adulthood
Bloch MH, Sukhodolsky DG, Dombrowski PA, Panza KE, Craiglow BG, Landeros‐Weisenberger A, Leckman JF, Peterson BS, Schultz RT. Poor fine‐motor and visuospatial skills predict persistence of pediatric‐onset obsessive‐compulsive disorder into adulthood. Journal Of Child Psychology And Psychiatry 2011, 52: 974-983. PMID: 21244423, PMCID: PMC3625937, DOI: 10.1111/j.1469-7610.2010.02366.x.Peer-Reviewed Original ResearchConceptsLong-term outcomesVisual-motor integrationPoor long-term outcomesCox proportional hazards modelBeery-Buktenica TestPediatric-onset obsessive-compulsive disorderFine motor skill deficitsPurdue pegboard taskCourse of symptomsProportional hazards modelPurdue Pegboard TestComorbid tic disordersAge of onsetVisuospatial skillsFuture longitudinal studiesOCD symptomsFine motor skillsCases remitNonverbal memory performanceObsessive-compulsive disorderNeuropsychiatric deficitsTic disordersMAIN OUTCOMEPegboard TestNeuropsychological testing
2010
Tic disorders: some key issues for DSM‐V
Walkup JT, Ferrão Y, Leckman JF, Stein DJ, Singer H. Tic disorders: some key issues for DSM‐V. Depression And Anxiety 2010, 27: 600-610. PMID: 20533370, DOI: 10.1002/da.20711.Peer-Reviewed Original Research
2008
Four-Factor Structure of Obsessive-Compulsive Disorder Symptoms in Children, Adolescents, and Adults
Stewart SE, Rosario MC, Baer L, Carter AS, Brown TA, Scharf JM, Illmann C, Leckman JF, Sukhodolsky D, Katsovich L, Rasmussen S, Goodman W, Delorme R, Leboyer M, Chabane N, Jenike MA, Geller DA, Pauls DL. Four-Factor Structure of Obsessive-Compulsive Disorder Symptoms in Children, Adolescents, and Adults. Journal Of The American Academy Of Child & Adolescent Psychiatry 2008, 47: 763-772. PMID: 18520961, DOI: 10.1097/chi.0b013e318172ef1e.Peer-Reviewed Original ResearchConceptsConfirmatory factor analysisAdult age groupsAge groupsAge group samplesAdult groupFour-factor solutionOngoing translational researchSymptom dimensionsPrevious confirmatory factor analysisObsessive-compulsive disorder symptomsMultiple-group confirmatory factor analysisCategory-based modelComparable model fitOCD symptom dimensions
2007
A Developmental Perspective on the Controversy Surrounding the Use of SSRIs to Treat Pediatric Depression
Leckman JF, King RA. A Developmental Perspective on the Controversy Surrounding the Use of SSRIs to Treat Pediatric Depression. American Journal Of Psychiatry 2007, 164: 1304-1306. PMID: 17728409, DOI: 10.1176/appi.ajp.2007.07050880.Peer-Reviewed Original Research
2006
Principal Components Analysis of Obsessive–Compulsive Disorder Symptoms in Children and Adolescents
Stewart SE, Rosario MC, Brown TA, Carter AS, Leckman JF, Sukhodolsky D, Katsovitch L, King R, Geller D, Pauls DL. Principal Components Analysis of Obsessive–Compulsive Disorder Symptoms in Children and Adolescents. Biological Psychiatry 2006, 61: 285-291. PMID: 17161383, DOI: 10.1016/j.biopsych.2006.08.040.Peer-Reviewed Original ResearchThe Dimensional Yale–Brown Obsessive–Compulsive Scale (DY-BOCS): an instrument for assessing obsessive–compulsive symptom dimensions
Rosario-Campos MC, Miguel EC, Quatrano S, Chacon P, Ferrao Y, Findley D, Katsovich L, Scahill L, King RA, Woody SR, Tolin D, Hollander E, Kano Y, Leckman JF. The Dimensional Yale–Brown Obsessive–Compulsive Scale (DY-BOCS): an instrument for assessing obsessive–compulsive symptom dimensions. Molecular Psychiatry 2006, 11: 495-504. PMID: 16432526, DOI: 10.1038/sj.mp.4001798.Peer-Reviewed Original Research
2004
Altered Interhemispheric Connectivity in Individuals With Tourettes Disorder
Plessen KJ, Wentzel-Larsen T, Hugdahl K, Feineigle P, Klein J, Staib LH, Leckman JF, Bansal R, Peterson BS. Altered Interhemispheric Connectivity in Individuals With Tourettes Disorder. American Journal Of Psychiatry 2004, 161: 2028-2037. PMID: 15514403, DOI: 10.1176/appi.ajp.161.11.2028.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAttention Deficit Disorder with HyperactivityCase-Control StudiesCerebral CortexComorbidityCorpus CallosumCross-Sectional StudiesFunctional LateralityHumansMagnetic Resonance ImagingMaleNeuronal PlasticityObsessive-Compulsive DisorderPrefrontal CortexSeverity of Illness IndexTourette SyndromeConceptsCorpus callosum sizeCallosum sizeTourette's disorderCorpus callosumCerebral hemispheresComparison subjectsCross-sectional case-control studyMidsagittal corpus callosum areaCorpus callosum areaCase-control studyEffects of medicationAge 30 yearsCortical inhibitory interneuronsHigh-resolution magnetic resonanceHealthy comparison subjectsMajor commissureComorbid illnessesTic symptomsOrbitofrontal cortical volumeCortical volumeInhibitory interneuronsInterhemispheric connectivityInhibitory inputsTic severityPrior evidence
2003
Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, King RA, Leckman JF, Staib L. Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome. JAMA Psychiatry 2003, 60: 415-424. PMID: 12695320, DOI: 10.1001/archpsyc.60.4.415.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesBasal gangliaCaudate nucleus volumeTourette syndromeGanglia volumesObsessive-compulsive disorderLenticular nucleus volumesTic symptomsNucleus volumeGilles dePathophysiology of TSPrior neuroleptic exposureHealthy control subjectsSeverity of ticsComorbid obsessive-compulsive disorderGreat clinical relevanceAttention-deficit/hyperactivity disorder (ADHD) symptomsHyperactivity disorder symptomsRepeated-measures analysisNeuroleptic exposureControl subjectsFunctional disturbancesTrait abnormalityClinical relevanceGangliaPhenomenology of tics and natural history of tic disorders
Leckman JF. Phenomenology of tics and natural history of tic disorders. Brain And Development 2003, 25: s24-s28. PMID: 14980368, DOI: 10.1016/s0387-7604(03)90004-0.Peer-Reviewed Original Research
2002
Development and natural history of mood disorders
Costello EJ, Pine DS, Hammen C, March JS, Plotsky PM, Weissman MM, Biederman J, Goldsmith HH, Kaufman J, Lewinsohn PM, Hellander M, Hoagwood K, Koretz DS, Nelson CA, Leckman JF. Development and natural history of mood disorders. Biological Psychiatry 2002, 52: 529-542. PMID: 12361667, DOI: 10.1016/s0006-3223(02)01372-0.Peer-Reviewed Original ResearchConceptsMood disordersMood disorders researchPediatric-onset bipolar disorderBipolar disorderUnipolar depressionNatural historySpecific risk factorsModel of pathogenesisPrecursor of depressionPsychotropic medicationsRisk infantsRisk factorsSuccessful treatmentHigh riskMultidisciplinary workgroupChildhood anxiety disordersJuvenile depressionDisorder researchEarly onsetProtective factorsAnxiety disordersPanel of expertsMental healthDisordersDepressionAssessment of Symptom Exacerbations in a Longitudinal Study of Children With Tourette's Syndrome or Obsessive-Compulsive Disorder
LIN H, YEH CB, PETERSON BS, SCAHILL L, GRANTZ H, FINDLEY DB, KATSOVICH L, OTKA J, LOMBROSO PJ, KING RA, LECKMAN JF. Assessment of Symptom Exacerbations in a Longitudinal Study of Children With Tourette's Syndrome or Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2002, 41: 1070-1077. PMID: 12218428, DOI: 10.1097/00004583-200209000-00007.Peer-Reviewed Original Research
2001
Adults With Early-Onset Obsessive-Compulsive Disorder
Rosario-Campos MC, Leckman JF, Mercadante MT, Shavitt RG, Prado HS, Sada P, Zamignani D, Miguel EC. Adults With Early-Onset Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2001, 158: 1899-1903. PMID: 11691698, DOI: 10.1176/appi.ajp.158.11.1899.Peer-Reviewed Original ResearchConceptsSymptom onsetObsessive-compulsive disorderSelective serotonin reuptake inhibitorsOCD patientsSerotonin reuptake inhibitorsEarlier symptom onsetEarly-onset groupLater symptom onsetOnset obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleComorbid tic disordersAdult OCD patientsObsessive Compulsive ScaleReuptake inhibitorsAdult outpatientsTic disordersTreatment outcomesOCD symptom onsetBimodal ageEarly onsetHeterogeneous disorderCompulsive ScaleDisordersAgePatientsRegional Brain and Ventricular Volumes in Tourette Syndrome
Peterson BS, Staib L, Scahill L, Zhang H, Anderson C, Leckman JF, Cohen DJ, Gore JC, Albert J, Webster R. Regional Brain and Ventricular Volumes in Tourette Syndrome. JAMA Psychiatry 2001, 58: 427-440. PMID: 11343521, DOI: 10.1001/archpsyc.58.5.427.Peer-Reviewed Original ResearchConceptsParieto-occipital regionsTourette syndromeTic symptomsCerebral volumeVentricular volumePathophysiology of TST subjectsWhite matter portionsThalamo-cortical circuitrySignificant inverse associationRegional cerebral volumesHigh-resolution anatomical magnetic resonance imagesStandard anatomical landmarksSex differencesAge-related findingsDorsal prefrontal regionsRegional brainCortico-striatoHealthy childrenHealthy controlsInverse associationHealthy subjectsOccipital volumeTS groupCortical regions
2000
The Psychiatric Symptoms of Rheumatic Fever
Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The Psychiatric Symptoms of Rheumatic Fever. American Journal Of Psychiatry 2000, 157: 2036-2038. PMID: 11097972, DOI: 10.1176/appi.ajp.157.12.2036.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderRheumatic feverSydenham's choreaTic disordersHigh riskComparison groupFever groupMajor depressive disorderDeficit hyperactivity disorderObsessive-compulsive disorderDepressive disorderRisk factorsPsychiatric symptomsPsychiatric disordersChoreaFeverNeuropsychiatric disordersObsessive-compulsive symptomsRating ScaleHyperactivity disorderSymptomsDisordersADHD symptomsChildrenSemistructured interviews
1999
Incremental Progress in Developmental Psychopathology: Simply Complex
Leckman JF. Incremental Progress in Developmental Psychopathology: Simply Complex. American Journal Of Psychiatry 1999, 156: 1495-1498. PMID: 10518156, DOI: 10.1176/ajp.156.10.1495.Peer-Reviewed Original ResearchEarly parental preoccupations and behaviors and their possible relationship to the symptoms of obsessive‐compulsive disorder
Leckman JF, Mayes LC, Feldman R, Evans DW, King RA, Cohen DJ. Early parental preoccupations and behaviors and their possible relationship to the symptoms of obsessive‐compulsive disorder. Acta Psychiatrica Scandinavica. Supplementum 1999, 100: 1-26. PMID: 10478283, DOI: 10.1111/j.1600-0447.1999.tb10951.x.Peer-Reviewed Original Research
1997
Obsessive-compulsive disorder with and without tics in an epidemiological sample of adolescents
Zohar AH, Pauls DL, Ratzoni G, Apter A, Dycian A, Binder M, King R, Leckman JF, Kron S, Cohen DJ. Obsessive-compulsive disorder with and without tics in an epidemiological sample of adolescents. American Journal Of Psychiatry 1997, 154: 274-276. PMID: 9016283, DOI: 10.1176/ajp.154.2.274.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEpidemiological sampleObsessive-compulsive spectrum disordersYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleYale-Brown scaleSpectrum disorderSexual imagesCompulsive ScaleChild psychiatristsDiagnostic InterviewAdolescentsComorbid ticsSex differencesDisordersTourette syndromeInterviewsGilles deAdulthoodObsessionGirlsBoysScale