2020
Pathways to a more peaceful and sustainable world: The transformative power of children in families
Britto PR, Hanöz-Penney S, Ponguta LA, Sunar D, Issa G, Hein SD, do Rosário MC, Almuneef MA, Korucu I, Togo Y, Kurbonov J, Choibekov N, Phan HTT, Fallon NS, Artukoğlu BB, Hartl FJ, Salah R, Fitzpatrick S, Connolly P, Dunne L, Miller S, Pruett K, Leckman JF. Pathways to a more peaceful and sustainable world: The transformative power of children in families. Development And Psychopathology 2020, 33: 409-420. PMID: 32935656, DOI: 10.1017/s0954579420000681.Peer-Reviewed Original ResearchAntibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity
Xu J, Liu RJ, Fahey S, Frick L, Leckman J, Vaccarino F, Duman RS, Williams K, Swedo S, Pittenger C. Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity. American Journal Of Psychiatry 2020, 178: 48-64. PMID: 32539528, PMCID: PMC8573771, DOI: 10.1176/appi.ajp.2020.19070698.Peer-Reviewed Original ResearchConceptsStriatal cholinergic interneuronsCholinergic interneuronsMouse brain slicesObsessive-compulsive disorderControl subjectsBrain slicesPediatric autoimmune neuropsychiatric disordersIntravenous immunoglobulin treatmentAutoimmune neuropsychiatric disordersAcute mouse brain slicesParvalbumin-expressing GABAergic interneuronsPediatric obsessive-compulsive disorderBrain antigensImmunoglobulin treatmentBaseline serumStreptococcal infectionCritical cellular targetsSymptom improvementGABAergic interneuronsInduced autoimmunityIgG antibodiesMouse slicesIndependent cohortBehavioral pathologyNeuron typesMaternal perceptions of father involvement among refugee and disadvantaged families in Beirut, Lebanon
Hein S, Bick J, Issa G, Aoude L, Maalouf C, Awar A, Nourallah S, Zonderman AL, Householder S, Katsovich L, Khoshnood K, Moore C, Salah R, Britto PR, Leckman JF, Ponguta LA. Maternal perceptions of father involvement among refugee and disadvantaged families in Beirut, Lebanon. PLOS ONE 2020, 15: e0229670. PMID: 32134961, PMCID: PMC7058288, DOI: 10.1371/journal.pone.0229670.Peer-Reviewed Original ResearchEffects of the Mother-Child Education Program on Parenting Stress and Disciplinary Practices Among Refugee and Other Marginalized Communities in Lebanon: A Pilot Randomized Controlled Trial
Ponguta LA, Issa G, Aoudeh L, Maalouf C, Hein SD, Zonderman AL, Katsovich L, Khoshnood K, Bick J, Awar A, Nourallah S, Householder S, Moore CC, Salah R, Britto PR, Leckman JF. Effects of the Mother-Child Education Program on Parenting Stress and Disciplinary Practices Among Refugee and Other Marginalized Communities in Lebanon: A Pilot Randomized Controlled Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: 727-738. PMID: 32014538, DOI: 10.1016/j.jaac.2019.12.010.Peer-Reviewed Original ResearchMeSH KeywordsChildChild, PreschoolFemaleHumansLebanonMother-Child RelationsMothersParentingPilot ProjectsRefugeesConceptsMother-Child Education ProgramIntervention groupWait-list control groupGroup-based interventionPost-intervention dataStress Index-Short FormModified intentionParenting Stress Index-Short FormIndex-Short FormUnderpowered analysesControl groupMother-child dyadsProgram attendanceEducation programsPilot studyEarly childhoodOutcomesTrialsHumanitarian settingsInterventionMultiple imputationMothersParenting stressChildrenChild outcomes
2019
Implementation Evaluation of the Mother‐Child Education Program Among Refugee and Other Vulnerable Communities in Lebanon
Ponguta LA, Issa G, Aoudeh L, Maalouf C, Nourallah S, Khoshnood K, Zonderman AL, Katsovich L, Moore C, Salah R, Al‐Soleiti M, Britto PR, Leckman JF. Implementation Evaluation of the Mother‐Child Education Program Among Refugee and Other Vulnerable Communities in Lebanon. New Directions For Child And Adolescent Development 2019, 2019: 91-116. PMID: 31509332, DOI: 10.1002/cad.20314.Peer-Reviewed Original ResearchConceptsMother-Child Education ProgramEarly childhood parenting programsEarly life adversityImplementation evaluationProgram uptakeParental knowledgeEarly childhood development programsEducation programsParenting ProgramChildhood development programsLow-income communitiesVulnerable settingsRCTsTrialsEvaluation
2018
A multicenter examination and strategic revisions of the Yale Global Tic Severity Scale
McGuire JF, Piacentini J, Storch EA, Murphy TK, Ricketts EJ, Woods DW, Walkup JW, Peterson AL, Wilhelm S, Lewin AB, McCracken JT, Leckman JF, Scahill L. A multicenter examination and strategic revisions of the Yale Global Tic Severity Scale. Neurology 2018, 90: e1711-e1719. PMID: 29653992, PMCID: PMC5952973, DOI: 10.1212/wnl.0000000000005474.Peer-Reviewed Original ResearchConceptsTic symptom severityTic scoreTIC numbersYale Global Tic Severity Scale (YGTSS) scoresSymptom severityYale Global Tic Severity ScaleYGTSS total tic scoreTotal tic scoreSimilar clinical characteristicsInternal consistencySeverity Scale scoreCross-sectional studyTic Severity ScaleDelphi consensus processClinical characteristicsPhonic ticsTic disordersMulticenter examinationImpairment scoresGood internal consistencySeverity ScaleScale scoreSymptom ChecklistDiagnostic InterviewStrong internal consistency
2017
Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum
Frick L, Rapanelli M, Jindachomthong K, Grant P, Leckman JF, Swedo S, Williams K, Pittenger C. Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum. Brain Behavior And Immunity 2017, 69: 304-311. PMID: 29233751, PMCID: PMC5857467, DOI: 10.1016/j.bbi.2017.12.004.Peer-Reviewed Original ResearchConceptsGroup A beta-hemolytic streptococciCholinergic interneuronsPediatric Autoimmune Neuropsychiatric Disorder AssociatedNeuropsychiatric Disorder AssociatedStriatal cholinergic interneuronsStriatum of miceBeta-hemolytic streptococciBrain antigensPANDAS patientsIntravenous immunoglobulinStriatal interneuronsNeuropsychiatric symptomsObsessive-compulsive disorderSymptom improvementGABAergic interneuronsClinical trialsHealthy controlsDisorders AssociatedTic disordersChildhood onsetInterneuronsLocus of pathologyElevated bindingAntibodiesStriatumLongitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS)
Leon J, Hommer R, Grant P, Farmer C, D’Souza P, Kessler R, Williams K, Leckman JF, Swedo S. Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). European Child & Adolescent Psychiatry 2017, 27: 637-643. PMID: 29119300, DOI: 10.1007/s00787-017-1077-9.Peer-Reviewed Original ResearchConceptsPediatric autoimmune neuropsychiatric disordersAutoimmune neuropsychiatric disordersIntravenous immunoglobulinStreptococcal infectionDose of IVIGNeuropsychiatric disordersPlacebo-controlled trialSignificant obsessive-compulsive symptomsPopulation of childrenCognitive behavioral therapySubacute illnessSydenham's choreaBlinded infusionChronic coursePsychiatric medicationsTreatment modalitiesSpecific symptomsChildhood-onset OCDLongitudinal courseNatural historyObsessive-compulsive symptomsBehavioral therapyExacerbationParents of participantsTelephone interviewsClinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part I—Psychiatric and Behavioral Interventions
Thienemann M, Murphy T, Leckman J, Shaw R, Williams K, Kapphahn C, Frankovich J, Geller D, Bernstein G, Chang K, Elia J, Swedo S. Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part I—Psychiatric and Behavioral Interventions. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 566-573. PMID: 28722481, PMCID: PMC5610394, DOI: 10.1089/cap.2016.0145.Peer-Reviewed Original ResearchConceptsPediatric acute-onset neuropsychiatric syndromeNeuropsychiatric syndromeInitial treatment doseEvidence-based interventionsPANDAS patientsImmunomodulatory therapyStreptococcal infectionChronic stageSymptomatic treatmentPsychopharmacologic interventionsPsychopharmacologic treatmentSymptom improvementSyndrome AssociatedConsensus guidelinesPsychotropic medicationsClinical managementInflammatory processCurrent guidelinesGuideline SeriesTreatment doseClinical experienceBehavioral symptomsVaried symptomsTherapeutic interventionsBehavioral interventionsElevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders
Guloksuz SA, Abali O, Cetin E, Gazioglu S, Deniz G, Yildirim A, Kawikova I, Guloksuz S, Leckman JF. Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders. Brazilian Journal Of Psychiatry 2017, 39: 195-200. PMID: 28099628, PMCID: PMC7111377, DOI: 10.1590/1516-4446-2015-1843.Peer-Reviewed Original ResearchConceptsTumor necrosis factor alphaNecrosis factor alphaS100B concentrationsPlasma concentrationsFactor alphaChildhood Autism Rating ScaleS100 calcium-binding protein BCalcium-binding protein BElevated plasma concentrationsTNF-α concentrationsAutism spectrum disorderIL-17AIL-10Cytokine concentrationsInflammatory cytokinesIL-6Peripheral concentrationsHealthy childrenIL-4Plasma levelsSpectrum disorderImmune functionInterferon gammaImmune systemS100B
2016
Nurturing care: promoting early childhood development
Britto PR, Lye SJ, Proulx K, Yousafzai AK, Matthews SG, Vaivada T, Perez-Escamilla R, Rao N, Ip P, Fernald LCH, MacMillan H, Hanson M, Wachs TD, Yao H, Yoshikawa H, Cerezo A, Leckman JF, Bhutta ZA, Group F. Nurturing care: promoting early childhood development. The Lancet 2016, 389: 91-102. PMID: 27717615, DOI: 10.1016/s0140-6736(16)31390-3.Peer-Reviewed Original ResearchRapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).
Gaughan T, Buckley A, Hommer R, Grant P, Williams K, Leckman JF, Swedo SE. Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). Journal Of Clinical Sleep Medicine 2016, 12: 1027-32. PMID: 27166296, PMCID: PMC4918985, DOI: 10.5664/jcsm.5942.Peer-Reviewed Original ResearchMeSH KeywordsChildChild, PreschoolFemaleHumansMaleObsessive-Compulsive DisorderPolysomnographyREM Sleep Behavior DisorderConceptsPediatric acute-onset neuropsychiatric syndromeNeuropsychiatric syndromeMotor disinhibitionRapid eye movement (REM) sleep abnormalitiesPeriodic limb movementsPopulation of childrenConsecutive subjectsPediatric neurologistsFull polysomnographyHand stereotypiesPolysomnographic investigationSleep abnormalitiesSleep architectureREM sleepPolysomnographyLimb movementsSyndromeAbnormalitiesChildrenSleepDisinhibitionExcessive movementSubjectsNeurologistsA Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD
Smith SD, Vitulano LA, Katsovich L, Li S, Moore C, Li F, Grantz H, Zheng X, Eicher V, Guloksuz S, Zheng Y, Dong J, Sukhodolsky DG, Leckman JF. A Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD. Journal Of Attention Disorders 2016, 24: 780-794. PMID: 27178060, PMCID: PMC5107355, DOI: 10.1177/1087054716647490.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityBehavior TherapyBrainChildChild, PreschoolHumansMemory, Short-TermTreatment OutcomeConceptsIntegrated brainComputerized cognitive remediation trainingCognitive remediation trainingSocial interventionsBehavior management strategiesRemediation trainingCognitive trainingMemory taskADHD symptomatologyADHD symptomsNeurocognitive testsTeacher ratingsBlinded clinician ratingGeneralized improvementADHDMultiple group comparisonsClinician ratingsMultiple domainsClinical functioningSignificant treatment effectOutcome measuresGroup comparisonsSecondary outcome measuresChildrenRatings
2015
Effect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: a prospective cohort study
Dalsgaard S, Leckman JF, Mortensen PB, Nielsen HS, Simonsen M. Effect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: a prospective cohort study. The Lancet Psychiatry 2015, 2: 702-709. PMID: 26249301, DOI: 10.1016/s2215-0366(15)00271-0.Peer-Reviewed Original ResearchConceptsAge 10 yearsAttention deficit hyperactivity disorderAge 12 yearsRisk of injuryPrevalence of injuriesCommon causeDeficit hyperactivity disorderPharmacological treatmentEmergency wardOdds ratioADHD drugsMajor public health importanceEmergency ward visitsHyperactivity disorderProspective cohort studyDanish national registersNon-treated childrenLarge disease burdenPublic health importanceEffects of drugsCohort studyWard visitsUntreated childrenAdjusted differenceDisease burdenMortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study
Dalsgaard S, Østergaard SD, Leckman JF, Mortensen PB, Pedersen MG. Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. The Lancet 2015, 385: 2190-2196. PMID: 25726514, DOI: 10.1016/s0140-6736(14)61684-6.Peer-Reviewed Original ResearchMeSH KeywordsAccidentsAdolescentAdultAge of OnsetAttention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityCase-Control StudiesCause of DeathChildChild, PreschoolConduct DisorderCross-Sectional StudiesDenmarkFemaleHumansInfantMalePoisson DistributionRisk FactorsSubstance-Related DisordersYoung AdultConceptsMortality rate ratiosAttention deficit hyperactivity disorderHighest mortality rate ratiosSubstance use disordersOppositional defiant disorderDeficit hyperactivity disorderExcess mortalityConduct disorderUse disordersMortality rateDefiant disorderHyperactivity disorderNationwide cohort studyDanish national registersCommon mental disordersExclusion of individualsCohort studyLundbeck FoundationCommon causeFamily historyCohort membersLarge cohortPsychiatric disordersUnnatural causesDanish individualsOxytocin-augmented labor and risk for autism in males
Weisman O, Agerbo E, Carter CS, Harris JC, Uldbjerg N, Henriksen TB, Thygesen M, Mortensen PB, Leckman JF, Dalsgaard S. Oxytocin-augmented labor and risk for autism in males. Behavioural Brain Research 2015, 284: 207-212. PMID: 25707712, DOI: 10.1016/j.bbr.2015.02.028.Peer-Reviewed Original ResearchConceptsSynthetic oxytocinInfant developmentICD-10 DCRSingleton live birthsAugmentation of laborAutistic disorderDose-dependent effectAugment laborMaternal exposureLive birthsModest associationEpidemiological analysisAdverse effectsOxytocinPlausible associationRiskMalesInconsistent findingsDisordersFuture studiesBirthAssociationAutismFindingsAugmentation
2014
Disordered Eating and Food Restrictions in Children with PANDAS/PANS
Toufexis MD, Hommer R, Gerardi DM, Grant P, Rothschild L, D'Souza P, Williams K, Leckman J, Swedo SE, Murphy TK. Disordered Eating and Food Restrictions in Children with PANDAS/PANS. Journal Of Child And Adolescent Psychopharmacology 2014, 25: 48-56. PMID: 25329522, PMCID: PMC4340640, DOI: 10.1089/cap.2014.0063.Peer-Reviewed Original ResearchConceptsPediatric acute-onset neuropsychiatric syndromeClinical presentationRestrictive food intake disorderFood intake disorderFear of chokingSymptom onsetMale predominanceNeuropsychiatric symptomsNeuropsychiatric syndromeSudden onsetFood intakeFood refusalDiagnostic criteriaFood restrictionMental disordersYounger ageBody image distortionStreptococcal bacteriaStatistical ManualSymptomsTreatment implicationsDisordersPresentationSensory issuesChildren
2013
Editorial Commentary: Resilience in child development – interconnected pathways to wellbeing
Panter‐Brick C, Leckman JF. Editorial Commentary: Resilience in child development – interconnected pathways to wellbeing. Journal Of Child Psychology And Psychiatry 2013, 54: 333-336. PMID: 23517424, DOI: 10.1111/jcpp.12057.Peer-Reviewed Original Research
2012
Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders
Brimberg L, Benhar I, Mascaro-Blanco A, Alvarez K, Lotan D, Winter C, Klein J, Moses AE, Somnier FE, Leckman JF, Swedo SE, Cunningham MW, Joel D. Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders. Neuropsychopharmacology 2012, 37: 2076-2087. PMID: 22534626, PMCID: PMC3398718, DOI: 10.1038/npp.2012.56.Peer-Reviewed Original ResearchConceptsSydenham's choreaNeuropsychiatric disordersStreptococcal exposureImmunological abnormalitiesMotor symptomsRat modelAnimal modelsSelective serotonin reuptake inhibitor paroxetineGroup A streptococcal infectionsSerotonin reuptake inhibitor paroxetineSK-N-SH neuronal cellsMale Lewis ratsNovel rat modelNew animal modelCalcium/calmodulin-dependent protein kinase IIRelated neuropsychiatric disordersStreptococcal infectionLewis ratsAntibody depositionBasal gangliaCalmodulin-dependent protein kinase IIDopamine D1GAS antigensGlutamate levelsD2 receptors
2011
Risperidone-Related Improvement of Irritability in Children with Autism Is not Associated with Changes in Serum of Epidermal Growth Factor and Interleukin-13
Tobiasova Z, van der Lingen KH, Scahill L, Leckman JF, Zhang Y, Chae W, McCracken JT, McDougle CJ, Vitiello B, Tierney E, Aman MG, Arnold LE, Katsovich L, Hoekstra PJ, Volkmar F, Bothwell AL, Kawikova I. Risperidone-Related Improvement of Irritability in Children with Autism Is not Associated with Changes in Serum of Epidermal Growth Factor and Interleukin-13. Journal Of Child And Adolescent Psychopharmacology 2011, 21: 555-564. PMID: 22070180, PMCID: PMC3279715, DOI: 10.1089/cap.2010.0134.Peer-Reviewed Original ResearchConceptsMedication-free subjectsEpidermal growth factorHealthy controlsInflammatory markersIL-13IL-1 receptor antagonistGrowth factorSerum inflammatory markersChemoattractant protein-1Placebo groupClinical improvementBaseline visitIL-17Serum levelsCytokine concentrationsInflammatory moleculesSerum concentrationsClinical trialsHealthy subjectsIL-1Interleukin-13RisperidoneAltered levelsProtein 1Diagnosis of autism