2007
Frontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis
Yoon DY, Gause CD, Leckman JF, Singer HS. Frontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis. Journal Of The Neurological Sciences 2007, 255: 50-56. PMID: 17337006, DOI: 10.1016/j.jns.2007.01.069.Peer-Reviewed Original ResearchConceptsTourette syndromeDopamine transporterReceptor densityPathophysiology of TSAlpha-adrenergic receptorsSex-matched controlsD2 receptor densityPostmortem brain tissueFrontal regionsDopaminergic dysfunctionNeurochemical abnormalitiesDopaminergic abnormalitiesNeurochemical markersTS patientsFrontal cortexSemiquantitative immunoblottingFrontal lobeBrain tissueTS subjectsTerminal markersOccipital regionAbnormalitiesVesicular dockingPathophysiologySyndrome
1995
[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder
Malison RT, McDougle CJ, van Dyck CH, Scahill L, Baldwin RM, Seibyl JP, Price LH, Leckman JF, Innis RB. [123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder. American Journal Of Psychiatry 1995, 152: 1359-1361. PMID: 7653693, DOI: 10.1176/ajp.152.9.1359.Peer-Reviewed Original ResearchConceptsTourette's disorderComparison subjectsDisorder patientsGender-matched healthy comparison subjectsStriatal dopamine transporter bindingStriatal dopamine transporter densityCIT SPECT imagingDopamine transporter levelsDopamine transporter densityDopamine transporter bindingPresynaptic dopamine functionTourette's disorder patientsPost-mortem findingsHealthy comparison subjectsSingle photon emissionBeta-carbomethoxy-3 betaAdult patientsCIT bindingPost-mortem resultsTransporter bindingDopamine functionTransporter densityTransporter levelsSPECT imagingDisorders