2012
Genome-wide association study of Tourette's syndrome
Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff R, Wagner M, Moessner R, Mirel D, Posthuma D, Sabatti C, Eskin E, Conti D, Knowles J, Ruiz-Linares A, Rouleau G, Purcell S, Heutink P, Oostra B, McMahon W, Freimer N, Cox N, Pauls D. Genome-wide association study of Tourette's syndrome. Molecular Psychiatry 2012, 18: 721-728. PMID: 22889924, PMCID: PMC3605224, DOI: 10.1038/mp.2012.69.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityCase-Control StudiesChromosomes, Human, Pair 9FemaleFibrillar CollagensGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansInternational CooperationMaleMeta-Analysis as TopicObsessive-Compulsive DisorderPolymorphism, Single NucleotideTourette SyndromeWhite PeopleYoung AdultConceptsGenome-wide association studiesFirst genome-wide association studyAssociation studiesTop signalsFull genetic architectureAncestry-matched controlsEuropean ancestry samplesGenetic architectureGWAS dataComplex inheritanceEuropean-derived populationsSusceptibility variantsSusceptibility genesEventual identificationEuropean ancestryCosta RicaChromosome 9q32Familial recurrence rateNorth AmericaComplete understandingAmerican populationCentral ValleyNeuropsychiatric diseasesDevelopmental disordersGenes
2002
Obsessive-compulsive disorders in children. Subtypes of OCD and their relation to infection with group A streptococci.
Thomsen PH, Leckman J. Obsessive-compulsive disorders in children. Subtypes of OCD and their relation to infection with group A streptococci. Ugeskrift For Laeger 2002, 164: 3763-7. PMID: 12362609.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSubtype of OCDBeta-haemolytic streptococciBody dysmorphic disorderAdult onsetSudden onsetNeurological abnormalitiesClinical consequencesPenicillin treatmentTourette syndromeSpecific subtypesObsessive-compulsive symptomsSuch disordersSubtypesDysmorphic disorderDisordersSyndromeInfectionDevelopmental disordersMore boysPresent reviewOnsetStreptococciRemissionRelapse
1999
Oxytocin, vasopressin, and autism: is there a connection?
Insel T, O’Brien D, Leckman J. Oxytocin, vasopressin, and autism: is there a connection? Biological Psychiatry 1999, 45: 145-157. PMID: 9951561, DOI: 10.1016/s0006-3223(98)00142-5.Peer-Reviewed Original ResearchConceptsVasopressin neurotransmissionAvailable preclinical evidencePreclinical evidenceClinical studiesAnimal studiesRodent brainPeptide receptorFeatures of autismOxytocinVasopressinGenetic disordersCompulsive behaviorsNeurotransmissionNormal expressionDevelopmental disordersSocial impairmentReceptorsCommunication deficitsDisordersSpecies-typical social behaviorsNeurobiological approachAutismEvidenceUnique effectsExpression