2023
Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome
Tsetsos F, Topaloudi A, Jain P, Yang Z, Yu D, Kolovos P, Tumer Z, Rizzo R, Hartmann A, Depienne C, Worbe Y, Müller-Vahl K, Cath D, Boomsma D, Wolanczyk T, Zekanowski C, Barta C, Nemoda Z, Tarnok Z, Padmanabhuni S, Buxbaum J, Grice D, Glennon J, Stefansson H, Hengerer B, Yannaki E, Stamatoyannopoulos J, Benaroya-Milshtein N, Cardona F, Hedderly T, Heyman I, Huyser C, Mir P, Morer A, Mueller N, Munchau A, Plessen K, Porcelli C, Roessner V, Walitza S, Schrag A, Martino D, Group T, TSAICG T, Barr C, Batterson J, Berlin C, Budman C, Coppola G, Cox N, Darrow S, Dion Y, Freimer N, Grados M, Greenberg E, Hirschtritt M, Huang A, Illmann C, King R, Kurlan R, Leckman J, Lyon G, Malaty I, McMahon W, Neale B, Okun M, Osiecki L, Robertson M, Rouleau G, Sandor P, Singer H, Smit J, Sul J, Initiative T, Androutsos C, Basha E, Farkas L, Fichna J, Janik P, Kapisyzi M, Karagiannidis I, Koumoula A, Nagy P, Puchala J, Szejko N, Szymanska U, Tsironi V, Group T, Apter A, Ball J, Bodmer B, Bognar E, Buse J, Vela M, Fremer C, Garcia-Delgar B, Gulisano M, Hagen A, Hagstrøm J, Madruga-Garrido M, Pellico A, Ruhrman D, Schnell J, Silvestri P, Skov L, Steinberg T, Gloor F, Turner V, Weidinger E, Network T, Alexander J, Aranyi T, Buisman W, Buitelaar J, Driessen N, Drineas P, Fan S, Forde N, Gerasch S, van den Heuvel O, Jespersgaard C, Kanaan A, Möller H, Nawaz M, Nespoli E, Pagliaroli L, Poelmans G, Pouwels P, Rizzo F, Veltman D, van der Werf Y, Widomska J, Zilhäo N, Group T, Brown L, Cheon K, Coffey B, Fernandez T, Gilbert D, Hong H, Ibanez-Gomez L, Kim E, Kim Y, Kim Y, Koh Y, Kook S, Kuperman S, Leventhal B, Maras A, Murphy T, Shin E, Song D, Song J, State M, Visscher F, Wang S, Zinner S, Tischfield J, Heiman G, Willsey A, Dietrich A, Davis L, Crowley J, Mathews C, Scharf J, Georgitsi M, Hoekstra P, Paschou P. Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome. Biological Psychiatry 2023, 96: 114-124. PMID: 36738982, PMCID: PMC10783199, DOI: 10.1016/j.biopsych.2023.01.023.Peer-Reviewed Original ResearchExpression quantitative trait lociGenome-wide significant lociWide association study dataComplex genetic architectureQuantitative trait lociAssociation study dataGenetic architectureTrait lociChromosome 5q15Significant lociSignificant enrichmentLociNovel insightsNeurodevelopmental disordersChildhood-onset neurodevelopmental disorderHistonesRNAsGenesPolygenic riskFuture studiesEnrichment
2021
Synaptic processes and immune-related pathways implicated in Tourette syndrome
Tsetsos F, Yu D, Sul JH, Huang AY, Illmann C, Osiecki L, Darrow SM, Hirschtritt ME, Greenberg E, Muller-Vahl KR, Stuhrmann M, Dion Y, Rouleau GA, Aschauer H, Stamenkovic M, Schlögelhofer M, Sandor P, Barr CL, Grados MA, Singer HS, Nöthen MM, Hebebrand J, Hinney A, King RA, Fernandez TV, Barta C, Tarnok Z, Nagy P, Depienne C, Worbe Y, Hartmann A, Budman CL, Rizzo R, Lyon GJ, McMahon WM, Batterson JR, Cath DC, Malaty IA, Okun MS, Berlin C, Woods DW, Lee PC, Jankovic J, Robertson MM, Gilbert DL, Brown LW, Coffey BJ, Dietrich A, Hoekstra PJ, Kuperman S, Zinner SH, Wagner M, Knowles JA, Jeremy Willsey A, Tischfield JA, Heiman GA, Cox NJ, Freimer NB, Neale BM, Davis LK, Coppola G, Mathews CA, Scharf JM, Paschou P, Barr C, Batterson J, Berlin C, Budman C, Cath D, Coppola G, Cox N, Darrow S, Davis L, Dion Y, Freimer N, Grados M, Greenberg E, Hirschtritt M, Huang A, Illmann C, King R, Kurlan R, Leckman J, Lyon G, Malaty I, Mathews C, McMahon W, Neale B, Okun M, Osiecki L, Robertson M, Rouleau G, Sandor P, Scharf J, Singer H, Smit J, Sul J, Yu D, Aschauer H, Barta C, Budman C, Cath D, Depienne C, Hartmann A, Hebebrand J, Konstantinidis A, Mathews C, Müller-Vahl K, Nagy P, Nöthen M, Paschou P, Rizzo R, Rouleau G, Sandor P, Scharf J, Schlögelhofer M, Stamenkovic M, Stuhrmann M, Tsetsos F, Tarnok Z, Wolanczyk T, Worbe Y, Brown L, Cheon K, Coffey B, Dietrich A, Fernandez T, Garcia-Delgar B, Gilbert D, Grice D, Hagstrøm J, Hedderly T, Heiman G, Heyman I, Hoekstra P, Huyser C, Kim Y, Kim Y, King R, Koh Y, Kook S, Kuperman S, Leventhal B, Madruga-Garrido M, Mir P, Morer A, Münchau A, Plessen K, Roessner V, Shin E, Song D, Song J, Tischfield J, Willsey A, Zinner S, Aschauer H, Barr C, Barta C, Batterson J, Berlin C, Brown L, Budman C, Cath D, Coffey B, Coppola G, Cox N, Darrow S, Davis L, Depienne C, Dietrich A, Dion Y, Fernandez T, Freimer N, Gilbert D, Grados M, Greenberg E, Hartmann A, Hebebrand J, Heiman G, Hirschtritt M, Hoekstra P, Huang A, Illmann C, Jankovic J, King R, Kuperman S, Lee P, Lyon G, Malaty I, Mathews C, McMahon W, Müller-Vahl K, Nagy P, Neale B, Nöthen M, Okun M, Osiecki L, Paschou P, Rizzo R, Robertson M, Rouleau G, Sandor P, Scharf J, Schlögelhofer M, Singer H, Stamenkovic M, Stuhrmann M, Sul J, Tarnok Z, Tischfield J, Tsetsos F, Willsey A, Woods D, Worbe Y, Yu D, Zinner S. Synaptic processes and immune-related pathways implicated in Tourette syndrome. Translational Psychiatry 2021, 11: 56. PMID: 33462189, PMCID: PMC7814139, DOI: 10.1038/s41398-020-01082-z.Peer-Reviewed Original ResearchConceptsLigand-gated ion channelsGene setsCell adhesionGenome-wide analysisComplex genetic architectureGenome-wide genotypic dataIon channelsSet of genesIndividual-level genotype dataSignificant gene setsAncestry-matched controlsParticular cell typeGenetic architectureImmune-related pathwaysSignaling processesGenotypic dataMAGMA analysisGenotype dataCell typesGenesIndication of involvementTS pathogenesisAdhesion moleculesGlial functionNew insights