2022
Course of Tic Severity in Tourette Syndrome: The First Two Decades
Leckman J, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y, Peterson B. Course of Tic Severity in Tourette Syndrome: The First Two Decades. 2022, 80-85. DOI: 10.4324/9780203822937-8.Peer-Reviewed Original ResearchYears of ageDecades of lifeTic severityTourette syndromeTS patientsTic onsetClinical evaluationPrevalence studySeverity of ticsInitial clinical evaluationConsistent time courseTime courseHigh rateOnset of pubertyInitial followPatient's coursePrognostic valueYale Child Study CenterBirth-year cohortsPatientsNatural historySyndromeCurve analysisSeverityStudy centers
2006
Fine‐motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome
Bloch MH, Sukhodolsky DG, Leckman JF, Schultz RT. Fine‐motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome. Journal Of Child Psychology And Psychiatry 2006, 47: 551-559. PMID: 16712631, DOI: 10.1111/j.1469-7610.2005.01561.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBasal GangliaChildFemaleFunctional LateralityHand StrengthHumansMaleMotor Skills DisordersNeuropsychological TestsObsessive-Compulsive DisorderPredictive Value of TestsPsychologyPsychomotor PerformanceSeverity of Illness IndexSocial BehaviorSurveys and QuestionnairesTourette SyndromeConceptsGlobal psychosocial functioningPurdue Pegboard TestFine motor skill deficitsTourette syndromeTic severityPegboard TestPsychosocial functioningTic symptomsTS patientsNeuropsychological testsStudy of TSBasal ganglia dysfunctionVisual-Motor Integration TestBeery Visual-Motor Integration TestLogistic regression analysisOrdinal logistic regression analysisFine motor coordinationMotor skill deficitsNeuropsychological testing batteryGanglia dysfunctionVisual-motor integrationClinical evaluationClinical assessmentClinical measuresNeuropsychological testingAdulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome
Bloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, Leckman JF. Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome. JAMA Pediatrics 2006, 160: 65-69. PMID: 16389213, PMCID: PMC2291298, DOI: 10.1001/archpedi.160.1.65.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic alpha-AgonistsAdultAntipsychotic AgentsAttention Deficit Disorder with HyperactivityBipolar DisorderChildDepressive DisorderFemaleFollow-Up StudiesHumansIntelligence TestsMaleObsessive-Compulsive DisorderProspective StudiesSchizophreniaSelective Serotonin Reuptake InhibitorsSeverity of Illness IndexTic DisordersTourette SyndromeConceptsTic symptomsTourette syndromeTic severitySymptom severityObsessive-compulsive disorderBaseline clinical measurementsChildhood-onset neuropsychiatric disorderOCD symptomsPercent of patientsProspective cohort studyPercent of subjectsOutpatient specialty clinicsThird of childrenThird of adultsAge 14 yearsStructured clinical evaluationCohort studyClinical courseComplete resolutionClinical evaluationPhonic ticsSpecialty clinicFollow-up interviewObsessive-compulsive symptom severityAverage age