2019
The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalence
2013
LONG‐TERM OUTCOME IN ADULTS WITH OBSESSIVE‐COMPULSIVE DISORDER
Bloch MH, Green C, Kichuk SA, Dombrowski PA, Wasylink S, Billingslea E, Landeros‐Weisenberger A, Kelmendi B, Goodman WK, Leckman JF, Coric V, Pittenger C. LONG‐TERM OUTCOME IN ADULTS WITH OBSESSIVE‐COMPULSIVE DISORDER. Depression And Anxiety 2013, 30: 716-722. PMID: 23532944, PMCID: PMC3932438, DOI: 10.1002/da.22103.Peer-Reviewed Original ResearchConceptsLong-term outcomesObsessive-compulsive disorderEvidence-based treatmentsAdult OCD patientsLong-term clinical outcomesSymptom severitySerotonin reuptake inhibitor medicationsOCD patientsPlacebo-controlled trialSerotonin reuptake inhibitorsReuptake inhibitor medicationsPercent of subjectsInitial responseSymptom dimensionsLater symptom severityOCD symptomsSignificant OCD symptomsOCD symptom dimensionsAdult patientsClinical characteristicsClinical improvementEligible subjectsPartial respondersInhibitor medicationReuptake inhibitors
2007
Deep brain stimulation in Tourette's syndrome
Bajwa RJ, de Lotbinière AJ, King RA, Jabbari B, Quatrano S, Kunze K, Scahill L, Leckman JF. Deep brain stimulation in Tourette's syndrome. Movement Disorders 2007, 22: 1346-1350. PMID: 17580320, DOI: 10.1002/mds.21398.Peer-Reviewed Original ResearchConceptsDeep brain stimulationBilateral deep brain stimulationTourette syndromeBrain stimulationIntractable Tourette syndromeProgressive neurological impairmentAdult patientsSevere ticsObsessive-compulsive disorderNeurological impairmentMotor ticsMedial partSyndromeHead jerkThalamusStimulationPatientsImpairmentGood effect
1995
[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder
Malison RT, McDougle CJ, van Dyck CH, Scahill L, Baldwin RM, Seibyl JP, Price LH, Leckman JF, Innis RB. [123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder. American Journal Of Psychiatry 1995, 152: 1359-1361. PMID: 7653693, DOI: 10.1176/ajp.152.9.1359.Peer-Reviewed Original ResearchConceptsTourette's disorderComparison subjectsDisorder patientsGender-matched healthy comparison subjectsStriatal dopamine transporter bindingStriatal dopamine transporter densityCIT SPECT imagingDopamine transporter levelsDopamine transporter densityDopamine transporter bindingPresynaptic dopamine functionTourette's disorder patientsPost-mortem findingsHealthy comparison subjectsSingle photon emissionBeta-carbomethoxy-3 betaAdult patientsCIT bindingPost-mortem resultsTransporter bindingDopamine functionTransporter densityTransporter levelsSPECT imagingDisorders