Clinically Anxious Individuals Show Disrupted Feedback between Inferior Frontal Gyrus and Prefrontal-Limbic Control Circuit
Cha J, DeDora D, Nedic S, Ide J, Greenberg T, Hajcak G, Mujica-Parodi L. Clinically Anxious Individuals Show Disrupted Feedback between Inferior Frontal Gyrus and Prefrontal-Limbic Control Circuit. Journal Of Neuroscience 2016, 36: 4708-4718. PMID: 27122030, PMCID: PMC6601720, DOI: 10.1523/jneurosci.1092-15.2016.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusVentromedial prefrontal cortexFrontal gyrusPrefrontal-limbic regionsAnxious individualsStimulus meaningNeurobiological responsesPrefrontal cortexFear generalization taskPrefrontal-limbic circuitsPrefrontal-limbic connectivityEmotion regulationAffective neurosciencePrefrontal-limbic systemGeneralization taskPerceptual similaritySimilarity gradientsPrefrontal regionsFMRI studyClinical anxietyAnxiety spectrumAnxiety severityVmPFCFunctional connectivityGyrus