2024
W35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders
Baldassarri S, Asch R, Hillmer A, Pietrzak R, DellaGioia N, Esterlis I, Davis M. W35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders. Drug And Alcohol Dependence 2024, 260: 110653. DOI: 10.1016/j.drugalcdep.2023.110653.Peer-Reviewed Original Research
2022
The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders
Asch R, Hillmer A, Baldassarri S, Esterlis I. The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders. International Review Of Neurobiology 2022, 168: 265-310. PMID: 36868631, DOI: 10.1016/bs.irn.2022.10.007.Peer-Reviewed Original ResearchConceptsPsychiatric disordersMetabotropic glutamate receptor 5Positron emission tomography studyGlutamate receptor 5Utility of PETEmission tomography studiesPromising therapeutic targetStress-related disordersNumerous psychiatric disordersTreatment trialsGlutamate neurotransmissionGlutamate systemMGlu5 expressionSubtype 5Treatment responseMood disordersRole of mGlu5Receptor 5Therapeutic targetPsychiatric conditionsMGlu5Tomography studySubstance useTrauma disordersDisordersImaging synaptic density in depression
Holmes SE, Abdallah C, Esterlis I. Imaging synaptic density in depression. Neuropsychopharmacology 2022, 48: 186-190. PMID: 35768568, PMCID: PMC9700860, DOI: 10.1038/s41386-022-01368-4.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPositron emission tomographySynaptic restorationSynaptic densityAdministration of ketamineMajor depressive disorderUnderstanding of depressionSynaptic alterationsSynaptic involvementDepressive disorderMonoamine systemsPreclinical workTreatment resistanceEffective treatmentDendritic spinesResonance imagingEmission tomographyHeterogeneous disorderDepressionDisordersMore researchInitial studyGliaKetamineBoutonsDifferential Role of mGluR5 in Cognitive Processes in Posttraumatic Stress Disorder and Major Depression
Esterlis I, DeBonee S, Cool R, Holmes S, Baldassari SR, Maruff P, Pietrzak RH, Davis MT. Differential Role of mGluR5 in Cognitive Processes in Posttraumatic Stress Disorder and Major Depression. Chronic Stress 2022, 6: 24705470221105804. PMID: 35958037, PMCID: PMC9358555, DOI: 10.1177/24705470221105804.Peer-Reviewed Original ResearchPosttraumatic stress disorderMajor depressive disorderHealthy adultsCognitive functioningFrontolimbic regionsStress disorderCognitive AssessmentCognitive alterationsPoor attentionCognitionMGluR5 availabilityRobust literatureDiagnostic groupsDifferent domainsMetabotropic glutamate receptor type 5Positron emission tomography scanDepressive disorderEmission tomography scanDisordersFunctioningRelationshipSmoking statusTomography scanParticipantsAdults
2021
Macro- and Microscale Stress–Associated Alterations in Brain Structure: Translational Link With Depression
Banasr M, Sanacora G, Esterlis I. Macro- and Microscale Stress–Associated Alterations in Brain Structure: Translational Link With Depression. Biological Psychiatry 2021, 90: 118-127. PMID: 34001371, DOI: 10.1016/j.biopsych.2021.04.004.Peer-Reviewed Original ResearchConceptsMajor depressive disorderStress-related disordersCytoarchitectural alterationsPathophysiology of MDDChronic stress pathologyDepressive-like behaviorChronic stress modelAnimal stress modelsPositron emission tomographyHuman brain tissueAstroglial alterationsSynaptic deficitsNeurochemical changesDepressive disorderBehavioral deficitsRodent modelsBrain tissueEmission tomographyDepression symptomatologyLiving brainBrain structuresNovel drugsTranslational linkStress pathologyDisorders