2024
Functional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Stiltner B, Fischer I, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak R. Functional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Psychiatric Research 2024, 171: 69-74. PMID: 38244335, DOI: 10.1016/j.jpsychires.2024.01.017.Peer-Reviewed Original ResearchConceptsModels of posttraumatic stress disorderPosttraumatic stress disorderNational Health and ResilienceU.S. military veteransArousal symptomsSuicidal ideationVeterans StudyCurrent depressionSymptom clustersMilitary veteransPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistAnxious arousal symptomsDysphoric arousal symptomsIntrusive symptom clustersOdds of suicidal ideationFunctional correlatesMulti-faceted disorderExternalizing behavioral symptomsAssociated with lower oddsAssociated with higher oddsSymptom structureAvoidance symptomsDSM-5
2023
Identifying significant correlates of purpose in life in older US military veterans: results from the national health and resilience in veterans study.
Fischer I, Feldman D, Tsai J, Harpaz-Rotem I, Lucas K, Schulenberg S, Pietrzak R. Identifying significant correlates of purpose in life in older US military veterans: results from the national health and resilience in veterans study. International Psychogeriatrics 2023, 35: 560-565. PMID: 36715004, DOI: 10.1017/s1041610222001223.Peer-Reviewed Original ResearchMeSH KeywordsAgedAgingCross-Sectional StudiesHumansResilience, PsychologicalStress Disorders, Post-TraumaticSurveys and QuestionnairesVeteransConceptsUS military veteransNational HealthMilitary veteransSignificant correlatesOlder US veteransAdverse health outcomesModifiable psychosocial factorsAdverse outcomesElastic net analysisUS veteransDepressive symptomsPsychosocial factorsHealth outcomesVeterans StudyPsychosocial variablesTreatment effortsCognitive outcomesCross-sectional dataVeteransOutcomesSocial supportCommunity integrationImportant correlatesHealthCorrelates
2021
Mindfulness as a Mediator Between Trauma Exposure and Mental Health Outcomes: Results From the National Health and Resilience in Veterans Study
Kachadourian LK, Harpaz-Rotem I, Tsai J, Southwick S, Pietrzak RH. Mindfulness as a Mediator Between Trauma Exposure and Mental Health Outcomes: Results From the National Health and Resilience in Veterans Study. Psychological Trauma Theory Research Practice And Policy 2021, 13: 223-230. PMID: 33475404, PMCID: PMC8500672, DOI: 10.1037/tra0000995.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAlcohol use disorderLifetime traumaTrauma-related negative affectPresent momentVeterans StudyU.S. veteransTrauma-related experiencesSuicidal ideationTraumatic life eventsLifetime trauma burdenMental health outcomesQuality of lifeMental health problemsTrauma remindersNegative affectMindful attentionTrauma exposurePTSD symptomsMental health issuesTraumatic eventsCumulative traumaStress disorderNoncombat veteransLife events
2018
Protective correlates of suicidality among veterans with histories of posttraumatic stress disorder and major depressive disorder: Results from the National Health and Resilience in Veterans Study
Kachadourian LK, Tsai J, Harpaz-Rotem I, Southwick SM, Pietrzak RH. Protective correlates of suicidality among veterans with histories of posttraumatic stress disorder and major depressive disorder: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2018, 246: 731-737. PMID: 30616162, DOI: 10.1016/j.jad.2018.12.058.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross-Sectional StudiesDepressive Disorder, MajorFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOptimismPrevalenceProtective FactorsResilience, PsychologicalRisk FactorsStress Disorders, Post-TraumaticSuicidal IdeationSuicideSuicide, AttemptedSurveys and QuestionnairesUnited StatesVeteransYoung AdultConceptsMajor depressive disorderPosttraumatic stress disorderProtective correlatesSuicidal ideationSuicide attemptsProtective factorsDepressive disorderNational HealthVeterans StudyMultivariable logistic regression analysisSuicidal behaviorStress disorderHistory of PTSDLogistic regression analysisSample of veteransAssessment of suicidalityLifetime suicide attemptsRisk factorsHigh-risk sampleTreatment approachesU.S. veteransWeb-based surveyCross-sectional natureSuicide riskSelf-report itemsBDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise
Pitts BL, Whealin JM, Harpaz-Rotem I, Duman RS, Krystal JH, Southwick SM, Pietrzak RH. BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise. Psychoneuroendocrinology 2018, 100: 198-202. PMID: 30388593, DOI: 10.1016/j.psyneuen.2018.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmino Acid SubstitutionBrain-Derived Neurotrophic FactorCase-Control StudiesExerciseFemaleHumansMaleMethionineMiddle AgedMilitary PersonnelPolymorphism, Single NucleotideProtective FactorsResilience, PsychologicalSeverity of Illness IndexStress Disorders, Post-TraumaticUnited StatesValineVeteransConceptsMet allele carriersBDNF Val66Met polymorphismAllele carriersVal66Met polymorphismPhysical exerciseGreater severityPTSD symptomsU.S. military veteransTrauma burdenBrain-derived neurotrophic factor (BDNF) Val66Met polymorphismPast-month PTSD symptomsNeurotrophic factor Val66Met polymorphismMilitary veteransLifetime trauma burdenHigh trauma burdenVal/ValAdrenal (HPA) axis reactivityPosttraumatic stress disorder (PTSD) symptomsBDNF releaseCurrent PTSD symptomsProtective effectRe-experiencing symptomsAxis reactivityPosttraumatic stress symptomsSymptoms
2017
Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study
Sippel LM, Han S, Watkins LE, Harpaz-Rotem I, Southwick SM, Krystal JH, Olff M, Sherva R, Farrer LA, Kranzler HR, Gelernter J, Pietrzak RH. Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study. Journal Of Psychiatric Research 2017, 94: 139-147. PMID: 28715704, PMCID: PMC5605420, DOI: 10.1016/j.jpsychires.2017.07.008.Peer-Reviewed Original ResearchMental and Physical Health Conditions in US Combat Veterans: Results From the National Health and Resilience in Veterans Study.
Thomas MM, Harpaz-Rotem I, Tsai J, Southwick SM, Pietrzak RH. Mental and Physical Health Conditions in US Combat Veterans: Results From the National Health and Resilience in Veterans Study. The Primary Care Companion For CNS Disorders 2017, 19 PMID: 28657698, DOI: 10.4088/pcc.17m02118.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsCardiovascular DiseasesCross-Sectional StudiesFemaleHealth StatusHumansMaleMental DisordersMental HealthMiddle AgedMigraine DisordersResilience, PsychologicalSex FactorsSocioeconomic FactorsSubstance-Related DisordersSuicideUnited StatesVeteransWar ExposureYoung AdultConceptsPhysical health conditionsPosttraumatic stress disorderOlder combat veteransCurrent posttraumatic stress disorderGreater oddsHealth conditionsChronic painHeart diseaseUS veteransNational HealthMigraine headacheCombat veteransSuicidal ideationVeterans StudyCurrent generalized anxiety disorderHeart attackVeterans Affairs Healthcare SystemLifetime posttraumatic stress disorderUS veteran populationElevated ratesPopulation-based burdenCurrent psychiatric disorderDrug use disordersMental health factorsGeneralized anxiety disorder
2016
Psychological resilience in U.S. military veterans: A 2-year, nationally representative prospective cohort study
Isaacs K, Mota NP, Tsai J, Harpaz-Rotem I, Cook JM, Kirwin PD, Krystal JH, Southwick SM, Pietrzak RH. Psychological resilience in U.S. military veterans: A 2-year, nationally representative prospective cohort study. Journal Of Psychiatric Research 2016, 84: 301-309. PMID: 27814502, DOI: 10.1016/j.jpsychires.2016.10.017.Peer-Reviewed Original ResearchConceptsU.S. military veteransTrauma-exposed veteransPsychological resilienceTrauma exposureMilitary veteransResilient groupTrauma-related psychological symptomsDistressed groupHigh trauma exposureCurrent psychological distressLifetime trauma exposurePhysical health difficultiesSense of purposeProspective cohort studyDispositional gratitudePosttraumatic stressTraumatic eventsEmotional stabilityPsychological distressCurrent distressLifetime traumaAnxiety disordersDistress symptomsHealth difficultiesPsychological symptomsHostility and telomere shortening among U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Watkins LE, Harpaz-Rotem I, Sippel LM, Krystal JH, Southwick SM, Pietrzak RH. Hostility and telomere shortening among U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Psychoneuroendocrinology 2016, 74: 251-257. PMID: 27689898, DOI: 10.1016/j.psyneuen.2016.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngerFemaleHealth SurveysHostilityHumansMaleMiddle AgedResilience, PsychologicalTelomere ShorteningUnited StatesVeteransConceptsU.S. military veteransClinical variablesNational HealthTelomere lengthMilitary veteransMultivariable binary logistic regression analysisVeterans StudyAccelerated cellular agingBinary logistic regression analysisLogistic regression analysisU.S. veteran populationNon-veteran populationsAge-related disordersPolymerase chain reaction methodChronic disordersRisk factorsChain reaction methodQuantitative polymerase chain reaction methodVeteran populationU.S. veteransSecondary analysisTreatment effortsVeteransRegression analysisBiological ageCorrelates of VA Mental Health Treatment Utilization Among OEF/OIF/OND Veterans: Resilience, Stigma, Social Support, Personality, and Beliefs About Treatment
DeViva JC, Sheerin CM, Southwick SM, Roy AM, Pietrzak RH, Harpaz-Rotem I. Correlates of VA Mental Health Treatment Utilization Among OEF/OIF/OND Veterans: Resilience, Stigma, Social Support, Personality, and Beliefs About Treatment. Psychological Trauma Theory Research Practice And Policy 2016, 8: 310-318. PMID: 26237497, DOI: 10.1037/tra0000075.Peer-Reviewed Original ResearchConceptsOEF/OIF/OND veteransPTSD symptomsAdaptive beliefsMental health careSocial supportPostdeployment social supportMeasures of resilienceMental health treatment utilizationDevelopment of interventionsMental health treatmentTreatment utilizationNT participantsPosttraumatic growthEmotional stabilityPP participantsMental health care utilizationPersonality factorsHealth careNT groupPP groupDifferent decision pointsHealth treatmentVA mental health careMental health service utilizationHealth care utilizationNature and determinants of suicidal ideation among U.S. veterans: Results from the national health and resilience in veterans study
Smith NB, Mota N, Tsai J, Monteith L, Harpaz-Rotem I, Southwick SM, Pietrzak RH. Nature and determinants of suicidal ideation among U.S. veterans: Results from the national health and resilience in veterans study. Journal Of Affective Disorders 2016, 197: 66-73. PMID: 26970267, DOI: 10.1016/j.jad.2016.02.069.Peer-Reviewed Original ResearchConceptsChronic suicidal ideationPhysical health difficultiesSuicidal ideationU.S. veteransProtective psychosocial characteristicsNational HealthPsychosocial characteristicsHealth difficultiesSI onsetMajor public health concernProspective cohort studyPublic health concernSubstance abuse historyWave 1Majority of veteransU.S. military veteransCohort studyProtective correlatesTwo-week timeframePsychiatric distressVeterans StudySociodemographic characteristicsSuicidal thoughtsHealth concernTreatment efforts
2014
Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study.
Tsai J, Harpaz-Rotem I, Armour C, Southwick SM, Krystal JH, Pietrzak RH. Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2014, 76: 546-53. PMID: 25562376, DOI: 10.4088/jcp.14m09091.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLifetime posttraumatic stress disorderHealth-related functioningMental health-related functioningDSM-5 posttraumatic stress disorderUS veteransSymptom clustersPTSD symptom clustersNational HealthVeterans StudyPTSD symptomsQuality of lifeDysphoric Arousal modelPosttraumatic stress disorder (PTSD) symptomsDSM-5 posttraumatic stress disorder symptomsDSM-5 PTSD symptom clustersHealth outcomesFemale veteransSuicidal ideationDSM-5 PTSD symptomsStress disorderSymptomsDisorder symptomsPTSD symptomatologyVeterans
2012
The Role of Coping, Resilience, and Social Support in Mediating the Relation Between PTSD and Social Functioning in Veterans Returning from Iraq and Afghanistan
Tsai J, Harpaz-Rotem I, Pietrzak RH, Southwick SM. The Role of Coping, Resilience, and Social Support in Mediating the Relation Between PTSD and Social Functioning in Veterans Returning from Iraq and Afghanistan. Psychiatry 2012, 75: 135-149. PMID: 22642433, DOI: 10.1521/psyc.2012.75.2.135.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAfghan Campaign 2001-AfghanistanChildCross-Sectional StudiesData Interpretation, StatisticalFamily RelationsFemaleHumansInterpersonal RelationsIraqIraq War, 2003-2011MalePersonal SatisfactionResilience, PsychologicalSelf ReportSocial BehaviorSocial SupportStress Disorders, Post-TraumaticUnited StatesVeteransConceptsPosttraumatic stress disorderTreatment-seeking veteransSocial functioningSocial supportSecure relationshipsLife satisfactionRole of copingPoor social functioningSeries of questionnairesLower life satisfactionAcceptance of changeRelationship satisfactionSocial avoidanceExcessive worryRomantic partnersFamily functioningStress disorderPsychotherapeutic interventionsCommon psychiatric disordersLess cohesionFunctioningPartner satisfactionMental health careVA primary careCoping
2011
Examining the dimensionality of combat-related posttraumatic stress and depressive symptoms in treatment-seeking OEF/OIF/OND veterans
Tsai J, Pietrzak RH, Southwick SM, Harpaz-Rotem I. Examining the dimensionality of combat-related posttraumatic stress and depressive symptoms in treatment-seeking OEF/OIF/OND veterans. Journal Of Affective Disorders 2011, 135: 310-314. PMID: 21782249, DOI: 10.1016/j.jad.2011.06.057.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAfghan Campaign 2001-BehaviorDepressionDepressive DisorderDisability EvaluationEthnicityFactor Analysis, StatisticalHumansIraq War, 2003-2011Military PersonnelPatient Acceptance of Health CareResilience, PsychologicalSocial SupportStress Disorders, Post-TraumaticSurveys and QuestionnairesVeteransVeterans Disability ClaimsConceptsPosttraumatic Stress Disorder Checklist-Military versionOEF/OIF/OND veteransPosttraumatic stress disorderFour-factor solutionCognitive copingPsychological resilienceStress disorderAlcohol useSocial supportCombat-related posttraumatic stress disorderTreatment-seeking veteransDimensionality of itemsDepressive symptomsPosttraumatic stressOperations Enduring Freedom/Iraqi Freedom/New DawnExploratory factor analysisPatient Health Questionnaire-9Cross-sectional designSymptom structureMore varianceFactor structureBodily disturbancesDetachment/Cluster of symptomsFactor scores