Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric Depression
de Asis J, Stern E, Alexopoulos G, Pan H, Van Gorp W, Blumberg H, Kalayam B, Eidelberg D, Kiosses D, Silbersweig D. Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric Depression. American Journal Of Psychiatry 2001, 158: 1321-1323. PMID: 11481171, DOI: 10.1176/appi.ajp.158.8.1321.Peer-Reviewed Original ResearchConceptsGeriatric depressionActivation deficitsComparison subjectsDorsal anterior cingulate gyrusPositron emission tomography scanEmission tomography scanDepressed geriatric patientsAnterior cingulate gyrusHealthy comparison subjectsElderly patientsGeriatric patientsFrontotemporal functionHippocampal dysfunctionTomography scanPrevalent disorderCingulate gyrusMemory dysfunctionWord generation taskPatientsMemory deficitsHippocampal activityActivation paradigmNeural substratesDepressionDysfunction