2001
Cerebral blood flow in obsessive–compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders
Hoehn-Saric R, Schlaepfer T, Greenberg B, McLeod D, Pearlson G, Wong S. Cerebral blood flow in obsessive–compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders. Psychiatry Research 2001, 108: 89-100. PMID: 11738543, DOI: 10.1016/s0925-4927(01)00114-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood Flow VelocityCerebral CortexDepressive Disorder, MajorDesipramineDominance, CerebralDouble-Blind MethodFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedObsessive-Compulsive DisorderRegional Blood FlowSertralineTomography, Emission-Computed, Single-PhotonTreatment OutcomeConceptsRegional cerebral blood flowHigher regional cerebral blood flowWeeks of treatmentCerebral blood flowYale-Brown Obsessive Compulsive ScaleBlood flowTemporal regionsType of medicationEffects of sertralineMajor depressive episodePrefrontal regional cerebral blood flowAdministration of medicationsPrefrontal regionsHMPAO SPECT scansEffect of treatmentObsessive Compulsive ScaleDiffuse reductionRCBF reductionStudy entryBasal gangliaDepressive episodeClinical changesMajor depressionDrug treatmentTreatment responders
1998
SPECT brain blood flow changes with continuous ligand infusion during previously-learned WCST performance
Tien A, Schlaepfer T, Orr W, Pearlson G. SPECT brain blood flow changes with continuous ligand infusion during previously-learned WCST performance. Psychiatry Research 1998, 82: 47-52. PMID: 9645550, DOI: 10.1016/s0925-4927(98)00003-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBrainCerebrovascular CirculationCognitionConcept FormationFrontal LobeHumansInfusions, IntravenousLearningMaleNeural InhibitionNeuropsychological TestsTomography, Emission-Computed, Single-PhotonConceptsWisconsin Card Sorting TestBrain blood flow changesBlood flow changesInferior parietal cortexBrain activation patternsBilateral inferior frontalBlood flowNormal subjectsTemporal cortexAnterior cingulateParietal cortexCard Sorting TestInferior frontalInfusionWCST performanceFlow changesCortexSorting TestHippocampusCaudateCingulate
1995
Pitfalls of SPECT Studies of Acute Ethanol-Induced Changes in Cerebral Blood Flow
SCHLAEPFER T, PEARLSON G. Pitfalls of SPECT Studies of Acute Ethanol-Induced Changes in Cerebral Blood Flow. American Journal Of Psychiatry 1995, 152: 1695-1695. PMID: 7485649, DOI: 10.1176/ajp.152.11.1695.Peer-Reviewed Original ResearchAlcohol DrinkingBrainCerebrovascular CirculationEuphoriaHalf-LifeHumansOrganotechnetium CompoundsOximesResearch DesignTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-Photon
1994
Altered cortical blood flow in HIV-seropositive individuals with and without dementia
Harris G, Pearlson G, McArthur J, Zeger S, LaFrance N. Altered cortical blood flow in HIV-seropositive individuals with and without dementia. AIDS 1994, 8: 495-500. PMID: 8011253, DOI: 10.1097/00002030-199404000-00012.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS Dementia ComplexCerebral CortexCerebrovascular CirculationFourier AnalysisHIV InfectionsHIV SeropositivityHumansMaleMiddle AgedTomography, Emission-Computed, Single-PhotonConceptsHIV-1-infected groupHIV-1-infected individualsNormal controlsBlood flowHIV-1-seropositive individualsRegional cerebral blood flowCortical profilesCerebral cortical perfusionCortical perfusion changesHIV-seropositive individualsCerebral perfusion abnormalitiesCortical blood flowCerebral blood flowSingle photon emissionTomographic imaging studiesHigh-frequency powerCortical perfusionCerebral cortexPerfusion abnormalitiesPerfusion changesSevere dementiaImaging studiesDistribution of radiotracerPhoton emissionDementia
1993
Single Photon Emission Computed Tomography in Obsessive-Compulsive Disorder
Harris G, Pearlson G, Hoehn-Saric R. Single Photon Emission Computed Tomography in Obsessive-Compulsive Disorder. JAMA Psychiatry 1993, 50: 498-499. PMID: 8498888, DOI: 10.1001/archpsyc.1993.01820180100015.Peer-Reviewed Original ResearchMeSH KeywordsCaudate NucleusCerebrovascular CirculationHumansObsessive-Compulsive DisorderOrganotechnetium CompoundsOximesTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonXenon RadioisotopesConceptsOrbital frontal regionsObsessive-compulsive disorderSingle photon emissionBlood flowRegional cerebral blood flowCortical blood flowGroup of patientsCerebral blood flowMedial frontal regionsSPECT studiesAnatomical locationPatientsCompulsive disorderPhoton emissionEt al1DisordersTomographyGroupMRI-guided region of interest placement on emission computed tomograms
Harris G, Pearlson G. MRI-guided region of interest placement on emission computed tomograms. Psychiatry Research 1993, 50: 57-63. PMID: 8511224, DOI: 10.1016/0925-4927(93)90024-c.Peer-Reviewed Original ResearchAnalysis of VarianceBrainHumansMagnetic Resonance ImagingReproducibility of ResultsTomography, Emission-Computed, Single-Photon
1991
Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease
Harris G, Links J, Pearlson G, Camargo E. Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease. Psychiatry Research 1991, 40: 167-180. PMID: 1780390, DOI: 10.1016/0925-4927(91)90008-e.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseBrain MappingCerebral CortexDominance, CerebralFemaleHumansMaleRegional Blood FlowTomography, Emission-Computed, Single-PhotonConceptsCerebral perfusionAlzheimer's diseaseRegional cerebral perfusionElderly control subjectsCerebral cortex functionControl subjectsCortex functionEntire cortexCircumferential profilesNeuroimaging studiesDiseaseIntersubject comparisonsPerfusionCortexDecrease variabilityPatientsIodoamphetamineBrain edgesPhysostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography
Tune L, Brandt J, Frost J, Harris G, Mayberg H, Steele C, Burns A, Sapp J, Folstein M, Wagner H, Pearlson G. Physostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography. Acta Psychiatrica Scandinavica. Supplementum 1991, 83: 61-65. PMID: 1897377, DOI: 10.1111/j.1600-0447.1991.tb03111.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmphetaminesBlood GlucoseBrainCerebrovascular CirculationDeoxyglucoseDose-Response Relationship, DrugDrug Administration ScheduleFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedNeuropsychological TestsPhysostigminePilot ProjectsTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonConceptsCerebral glucose metabolismCerebral blood flowSingle photon emission tomographyPhoton emission tomographyPositron emission tomographyBlood flowEmission tomographyGlucose metabolismAlzheimer's diseaseRegional cerebral glucose metabolismSignificant clinical improvementCognitive functioningClinical improvementMost patientsIntravenous administrationPatientsDiseasePhysostigmineTomographyBrain activityPreliminary findingsMetabolismPronounced improvementPathophysiologyIllness