1987
Mania After Brain Injury: A Controlled Study of Causative Factors
Starkstein S, Pearlson G, Boston J, Robinson R. Mania After Brain Injury: A Controlled Study of Causative Factors. JAMA Neurology 1987, 44: 1069-1073. PMID: 3632381, DOI: 10.1001/archneur.1987.00520220065019.Peer-Reviewed Original ResearchConceptsBrain injuryVentricle/brain ratiosPossible family historyFocal brain injurySecondary maniaRight hemisphere lesionsSubcortical atrophyBrain ratioDepressive episodeLimbic areasManic patientsFamily historyManic syndromeFocal lesionsAffective disordersPatientsInjuryLesionsCausative factorsRare occurrenceHemisphere lesionsGenetic loadingRight hemisphereManiaRight hemisphere involvement
1982
Intracortical kainic acid induces an assymmetrical behavioral response in the rat
Kubos K, Pearlson G, Robinson R. Intracortical kainic acid induces an assymmetrical behavioral response in the rat. Brain Research 1982, 239: 303-309. PMID: 7093686, DOI: 10.1016/0006-8993(82)90857-5.Peer-Reviewed Original ResearchConceptsKainic acidCortical noradrenergic terminalsDay postoperative periodRight frontal cortexNoradrenergic terminalsPostoperative periodRight hemisphere lesionsSpontaneous hyperactivityFrontal cortexIdentical injectionsHemisphere lesionsNanomolar dosesLeft hemisphereHyperactivityRatsNeural asymmetriesInjectionBehavioral responsesPrevious studiesLesionsCortexDosesWeeks