Prophylactic Efficacy of Riluzole against Anxiety- and Depressive-Like Behaviors in Two Rodent Stress Models
Bansal Y, Fee C, Misquitta K, Codeluppi S, Sibille E, Berman R, Coric V, Sanacora G, Banasr M. Prophylactic Efficacy of Riluzole against Anxiety- and Depressive-Like Behaviors in Two Rodent Stress Models. Complex Psychiatry 2023, 9: 57-69. PMID: 37101541, PMCID: PMC10123365, DOI: 10.1159/000529534.Peer-Reviewed Original ResearchUnpredictable chronic mild stressAnhedonia-like behaviorHelplessness-like behaviorStress-related disordersFirst-line antidepressant drugsNovelty-induced hypophagia testDepressive-like behaviorChronic mild stressHigh relapse rateSucrose consumption testNovelty-suppressed feedingRodent stress modelsMajor depressive disorderAnxiety-like behaviorOpen field testBehavioral emotionalityRiluzole efficacyRiluzole treatmentHypophagia testRelapse rateProphylactic medicationStress-related illnessesProphylactic efficacyProphylactic treatmentSpecific symptom dimensions