The genetics of severe depression
Franklin C, Achtyes E, Altinay M, Bailey K, Bhati M, Carr B, Conroy S, Husain M, Khurshid K, Lencz T, McDonald W, Mickey B, Murrough J, Nestor S, Nickl-Jockschat T, Nikayin S, Reeves K, Reti I, Selek S, Sanacora G, Trapp N, Viswanath B, Wright J, Sullivan P, Zandi P, Potash J. The genetics of severe depression. Molecular Psychiatry 2024, 1-10. PMID: 39406997, DOI: 10.1038/s41380-024-02731-1.Peer-Reviewed Original ResearchGenome-wide association studiesSevere depressionGenome-wide significant lociWhole-exome sequencing studiesAssociated with dysphoriaGenome-wide lociGenome-wide interrogationExome sequencing studiesEarly-onset illnessDegree of impairmentDepressive disorderMDD phenotypesSignificant lociAssociation studiesClinical markers of severitySequencing studiesMDDLociRare variantsClinically actionable findingsEstimates of heritabilityDepressionFamily-basedSevere formGenetics