2016
Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies
Hermes G, Sanacora G. Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies. 2016, 73-98. DOI: 10.1007/978-3-319-42925-0_6.Peer-Reviewed Original ResearchAntidepressant activityPreclinical studiesAntidepressant actionKetamine's mechanismPreclinical literatureRodent modelsRapid onsetBrain-derived neurotrophic factor (BDNF) expressionBehavioral effectsClassic antidepressant drugsRapid antidepressant activityNeurotrophic factor expressionChronic stressor exposureReceptor-targeted drugsNovel drug developmentAntidepressant propertiesKetamine effectsClinical trialsAntidepressant drugsSynaptic plasticityReceptor activationClinical settingFactor expressionStressor exposureDurable effects
2001
ECS-Induced Mossy Fiber Sprouting and BDNF Expression Are Attenuated By Ketamine Pretreatment
Chen A, Shin K, Duman R, Sanacora G. ECS-Induced Mossy Fiber Sprouting and BDNF Expression Are Attenuated By Ketamine Pretreatment. Journal Of Ect 2001, 17: 27-32. PMID: 11281511, DOI: 10.1097/00124509-200103000-00006.Peer-Reviewed Original ResearchConceptsNeurotrophic factor expressionMossy fiber sproutingBDNF expressionElectroconvulsive seizuresKetamine pretreatmentSeizure durationFiber sproutingDentate gyrusBrain-derived neurotrophic factor (BDNF) expressionFactor expressionChronic electroconvulsive seizureSpecific anesthetic agentsTreatment of depressionNMDA receptor activationMossy fiber pathwayUse of ECTMedial prefrontal cortexTimm histochemistryCortical atrophySeizure intensitySeizure activityMajor depressionNMDA antagonistsNMDA receptorsAnesthetic agents