2022
L-type calcium channel regulation of dopamine activity in the ventral tegmental area to nucleus accumbens pathway: Implications for substance use, mood disorders and co-morbidities
Nunes E, Addy N. L-type calcium channel regulation of dopamine activity in the ventral tegmental area to nucleus accumbens pathway: Implications for substance use, mood disorders and co-morbidities. Neuropharmacology 2022, 224: 109336. PMID: 36414149, PMCID: PMC11215796, DOI: 10.1016/j.neuropharm.2022.109336.Peer-Reviewed Original ResearchConceptsL-type calcium channelsVentral tegmental areaPre-clinical modelsTegmental areaSubstance useLTCC blockersMood disordersCalcium channelsCo-morbid psychiatric diagnosesDA neuronal activityVoltage-gated calcium channelsMood-related behaviorsSubstance use disordersCalcium channel regulationStress-induced plasticityAccumbens pathwayCardiac medicationsDopamine neuronsLTCC subtypesNeuronal activityNeuronal firingUse disordersPsychiatric diagnosisCalcium entryDopamine activityCholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders
Nunes EJ, Kebede N, Bagdas D, Addy NA. Cholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders. Journal Of The Experimental Analysis Of Behavior 2022, 117: 404-419. PMID: 35286712, PMCID: PMC9743782, DOI: 10.1002/jeab.747.Peer-Reviewed Original ResearchConceptsMood disordersSubstance useActivational componentsMotivated behaviorComorbid substance useMesolimbic dopamine systemDA releaseCholinergic activityCholinergic transmissionImportant neuromodulatorCholinergic dysregulationDA regulationDopamine systemDA signalingActivational aspectsDisease statesDisordersAversive stimuliPossible roleHealthy stateCholinergicAcetylcholineStimuliEtiologyIllness
2021
Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats
Bagdas D, Rupprecht LE, Nunes EJ, Schillinger E, Immanuel JJ, Addy NA. Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats. Nicotine & Tobacco Research 2021, 24: 753-760. PMID: 34918123, PMCID: PMC8962681, DOI: 10.1093/ntr/ntab241.Peer-Reviewed Original ResearchConceptsTaste reactivity testOrosensory experienceAversive responsesAbuse liabilityAversive valueAversive reactionsHedonic responsesNicotine rewardTaking behaviorIntraoral cathetersImpact of mentholReactivity testOlfactory cuesOrofacial movementsDislikingLikingNicotine responseTaste stimuliSex-dependent mannerOral nicotineNicotine inducesNicotineCuesIngestive responsesExperience
2013
Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: Effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors
Nunes E, Randall P, Podurgiel S, Correa M, Salamone J. Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: Effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors. Neuroscience & Biobehavioral Reviews 2013, 37: 2015-2025. PMID: 23583616, DOI: 10.1016/j.neubiorev.2013.04.002.Peer-Reviewed Original ResearchConceptsEffort-related choice behaviorMuscarinic acetylcholine receptorsDA antagonismEffort-related processesNAc coreAcetylcholine receptorsFood motivationAspects of appetiteControl site dorsalPrimary food motivationA2A receptor stimulationMuscarinic antagonist scopolamineDA D2 antagonistsAction of pilocarpineAdenosine A2A receptorsAdenosine A2A antagonistsEffects of drugsEffort-related choiceFood-seeking behaviorSites dorsalChow intakeDA depletionDA transmissionMuscarinic receptorsD2 antagonist
2012
THE BEHAVIORAL PHARMACOLOGY OF EFFORT‐RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND
Salamone J, Correa M, Nunes E, Randall P, Pardo M. THE BEHAVIORAL PHARMACOLOGY OF EFFORT‐RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND. Journal Of The Experimental Analysis Of Behavior 2012, 97: 125-146. PMID: 22287808, PMCID: PMC3266736, DOI: 10.1901/jeab.2012.97-125.Peer-Reviewed Original ResearchConceptsEffort-related choice behaviorDA depletionAccumbens DA depletionsNucleus accumbens DAAccumbens DAFood-reinforced behaviorDA transmissionMesolimbic DAPsychomotor slowingEffort-related functionsNeurological disordersFood-reinforced tasksBrain structuresDrug abuseAccumbens DA transmissionBehavioral pharmacologyHigh response requirementsRatsBrain systemsPresent reviewPrimary reinforcerAntagonism