Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism
Nunes E, Randall P, Santerre J, Given A, Sager T, Correa M, Salamone J. Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism. Neuroscience 2010, 170: 268-280. PMID: 20600675, PMCID: PMC3268040, DOI: 10.1016/j.neuroscience.2010.05.068.Peer-Reviewed Original ResearchConceptsEffects of dopamineEffects of ecopipamSame striatal neuronsEffects of adenosineAbility of adenosineEffort-related impairmentsEffort-related choiceFood-seeking behaviorEffort-related choice behaviorConcurrent leverChow intakeDA transmissionSelective adenosine antagonistsStriatal neuronsReceptor antagonistRodent chowDopamine D1D2 antagonismPsychiatric symptomsPsychomotor slowingAdenosine antagonistEffort-related processesBrain circuitryAntagonistMesolimbic dopamine