2013
Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task
Nunes E, Randall P, Estrada A, Epling B, Hart E, Lee C, Baqi Y, Müller C, Correa M, Salamone J. Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task. Psychopharmacology 2013, 231: 727-736. PMID: 24136220, PMCID: PMC4468782, DOI: 10.1007/s00213-013-3285-4.Peer-Reviewed Original ResearchConceptsPro-inflammatory cytokines interleukinIL-1βMotivational symptomsEffort-related choice behaviorCytokines interleukinLow dosesEffort-related motivational effectsEffort-related motivational symptomsPro-inflammatory cytokinesLoss of appetiteInvolvement of cytokinesAdministration of cytokinesRatio 5 leverSame dose rangeAdenosine A2A antagonistsEffort-related impairmentsCore body temperatureObjectivesThe present experimentsChow intakeMSX-3ResultsIL-1βAvailable chowFood intakeTendency of ratsA2A antagonists
2012
The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation
Salamone J, Correa M, Randall P, Nunes E, Pardo M, Lopez-Cruz L. The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation. 2012, 493-512. DOI: 10.1007/978-1-4614-3903-5_23.Peer-Reviewed Original ResearchIntra-accumbens injectionsDA depletionReceptor antagonistAccumbens DA depletionsEffort-related processesAdenosine A2A receptor antagonistA1 receptor antagonistAdenosine A2A agonistDA D2 antagonistsA2A receptor antagonistsRole of adenosineAdenosine A2A receptorsEffort-related decision makingEffort-related choice behaviorBrain dopamineNeuromodulator adenosineD2 antagonistD2 antagonismA2A agonistNucleus accumbensStriatal circuitsTendency of ratsMotivational symptomsA2A receptorsPathological aspects
2010
Role of dopamineadenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation
Salamone J, Correa M, Farrar A, Nunes E, Collins L. Role of dopamineadenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation. Future Neurology 2010, 5: 377-392. DOI: 10.2217/fnl.10.19.Peer-Reviewed Original ResearchEffort-related processesDopamine depletionEffort-related decision makingEffort-related decisionTendency of ratsEffort-related choiceEnergy-related disordersActivational aspectsIntra-accumbens injectionsFood motivationBrain circuitryAccumbens dopamine depletionsBrain dopamineNeuromodulator adenosineMotivationNucleus accumbensPathological aspectsDecision makingDopamine DRecent evidenceAntagonistAdenosineAnergiaAspectsAccumbens