2012
THE BEHAVIORAL PHARMACOLOGY OF EFFORT‐RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND
Salamone J, Correa M, Nunes E, Randall P, Pardo M. THE BEHAVIORAL PHARMACOLOGY OF EFFORT‐RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND. Journal Of The Experimental Analysis Of Behavior 2012, 97: 125-146. PMID: 22287808, PMCID: PMC3266736, DOI: 10.1901/jeab.2012.97-125.Peer-Reviewed Original ResearchConceptsEffort-related choice behaviorDA depletionAccumbens DA depletionsNucleus accumbens DAAccumbens DAFood-reinforced behaviorDA transmissionMesolimbic DAPsychomotor slowingEffort-related functionsNeurological disordersFood-reinforced tasksBrain structuresDrug abuseAccumbens DA transmissionBehavioral pharmacologyHigh response requirementsRatsBrain systemsPresent reviewPrimary reinforcerAntagonism
2010
The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior
Randall P, Vemuri V, Segovia K, Torres E, Hosmer S, Nunes E, Santerre J, Makriyannis A, Salamone J. The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior. Pharmacology Biochemistry And Behavior 2010, 97: 179-184. PMID: 20713079, PMCID: PMC3522179, DOI: 10.1016/j.pbb.2010.07.021.Peer-Reviewed Original ResearchConceptsAppetite suppressant drugsFood-motivated behaviorHigh-fat dietCentral nervous systemFood-reinforced behaviorSame dose rangeCB1 inverse agonistsUndesirable side effectsChow intakeIntraperitoneal administrationAM6545CB1 receptorsAppetite suppressantsCannabinoid antagonistFood intakeHigh doseSide effectsNervous systemPoor penetrabilityInverse agonistNeutral antagonistsDose rangeMild suppressionIntakeAntagonist
2009
Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats
Sink K, Segovia K, Nunes E, Collins L, Vemuri V, Thakur G, Makriyannis A, Salamone J. Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats. Psychopharmacology 2009, 206: 223-232. PMID: 19588124, PMCID: PMC4425366, DOI: 10.1007/s00213-009-1602-8.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBehavior, AnimalConditioning, OperantDose-Response Relationship, DrugDrug Administration RoutesDrug InteractionsEatingFood DeprivationInjections, IntraventricularMaleMotor ActivityPiperidinesPyrazolesRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Reinforcement ScheduleReinforcement, PsychologyConceptsFood-reinforced behaviorCB1 receptorsLocomotor suppressionFood-motivated behaviorCannabinoid CB1 receptorsCB1 neutral antagonistsSame dose rangeModulation of locomotionIntracerebroventricular administrationICV administrationLocus of actionLower brainstemReceptor transmissionPeripheral receptorsSystemic administrationLateral ventricleAppetite suppressantsNucleus accumbensAM251AM4113Inverse agonistNeutral antagonistsDose rangeAdministrationReceptors