The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation
Salamone J, Correa M, Randall P, Nunes E, Pardo M, Lopez-Cruz L. The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation. 2012, 493-512. DOI: 10.1007/978-1-4614-3903-5_23.Peer-Reviewed Original ResearchIntra-accumbens injectionsDA depletionReceptor antagonistAccumbens DA depletionsEffort-related processesAdenosine A2A receptor antagonistA1 receptor antagonistAdenosine A2A agonistDA D2 antagonistsA2A receptor antagonistsRole of adenosineAdenosine A2A receptorsEffort-related decision makingEffort-related choice behaviorBrain dopamineNeuromodulator adenosineD2 antagonistD2 antagonismA2A agonistNucleus accumbensStriatal circuitsTendency of ratsMotivational symptomsA2A receptorsPathological aspectsTHE BEHAVIORAL PHARMACOLOGY OF EFFORT‐RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND
Salamone J, Correa M, Nunes E, Randall P, Pardo M. THE BEHAVIORAL PHARMACOLOGY OF EFFORT‐RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND. Journal Of The Experimental Analysis Of Behavior 2012, 97: 125-146. PMID: 22287808, PMCID: PMC3266736, DOI: 10.1901/jeab.2012.97-125.Peer-Reviewed Original ResearchConceptsEffort-related choice behaviorDA depletionAccumbens DA depletionsNucleus accumbens DAAccumbens DAFood-reinforced behaviorDA transmissionMesolimbic DAPsychomotor slowingEffort-related functionsNeurological disordersFood-reinforced tasksBrain structuresDrug abuseAccumbens DA transmissionBehavioral pharmacologyHigh response requirementsRatsBrain systemsPresent reviewPrimary reinforcerAntagonism