An ADH1B Variant and Peer Drinking in Progression to Adolescent Drinking Milestones: Evidence of a Gene‐by‐Environment Interaction
Olfson E, Edenberg HJ, Nurnberger J, Agrawal A, Bucholz KK, Almasy LA, Chorlian D, Dick DM, Hesselbrock VM, Kramer JR, Kuperman S, Porjesz B, Schuckit MA, Tischfield JA, Wang J, Wetherill L, Foroud TM, Rice J, Goate A, Bierut LJ. An ADH1B Variant and Peer Drinking in Progression to Adolescent Drinking Milestones: Evidence of a Gene‐by‐Environment Interaction. Alcohol Clinical And Experimental Research 2014, 38: 2541-2549. PMID: 25257461, PMCID: PMC4256939, DOI: 10.1111/acer.12524.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlcohol DehydrogenaseAlcohol DrinkingAlcohol-Related DisordersAlcoholismAllelesChildDisease ProgressionDrinking BehaviorFemaleGene-Environment InteractionGenetic VariationHumansLongitudinal StudiesMalePeer GroupProportional Hazards ModelsPsychological DistanceRisk FactorsSocial EnvironmentUnited StatesYoung AdultConceptsProtective effectDSM-5 symptomsFirst intoxicationImportant public health concernProportional hazards regressionAlcohol use disorder symptomsADH1B variantsDrinking milestonesAlcohol use disorderDrinking behaviorPublic health concernDiverse adult populationsAlcohol dehydrogenase 1BFinal modelPrimary outcomeHazards regressionAfrican American individualsRisk factorsUse disordersAdult populationAge 18SymptomsHealth concernIntoxicationDisorder symptoms