2017
Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder
Scheinost D, Holmes SE, DellaGioia N, Schleifer C, Matuskey D, Abdallah CG, Hampson M, Krystal JH, Anticevic A, Esterlis I. Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder. Neuropsychopharmacology 2017, 43: 1119-1127. PMID: 28944772, PMCID: PMC5854800, DOI: 10.1038/npp.2017.229.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAnterior cingulate cortexIntrinsic functional connectivityMedial prefrontal cortexFunctional connectivityLarge-scale brain networksDepressive disorderMDD groupAnatomical covarianceBrain networksUnmedicated major depressive disorderWhole-brain intrinsic functional connectivitySystem-level disorderIntrinsic connectivity distributionRegional brain structureMultiple brain networksAltered connectivityCommon findingHealthy comparison participantsDepressive symptomsAltered volumeUnmedicated individualsLocal circuitryCingulate cortexDepressive symptomatology
2016
Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals
Zakiniaeiz Y, Scheinost D, Seo D, Sinha R, Constable RT. Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals. NeuroImage Clinical 2016, 13: 181-187. PMID: 27981033, PMCID: PMC5144743, DOI: 10.1016/j.nicl.2016.10.019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAUD patientsFunctional connectivityCingulate cortexCox proportional hazards regressionChronic relapsing illnessWhole-brain investigationProportional hazards regressionFunctional connectivity differencesAlcohol-dependent patientsVoxel-wise connectivityNeutral cuesAlcohol-dependent individualsHealthy control participantsFunctional magnetic resonanceRelapse measuresHazards regressionSubsequent relapseDependent patientsInpatient treatmentAlcohol relapseFuture relapsePatientsAlcohol dependenceConnectivity differences
2013
Real-time fMRI links subjective experience with brain activity during focused attention
Garrison KA, Scheinost D, Worhunsky PD, Elwafi HM, Thornhill TA, Thompson E, Saron C, Desbordes G, Kober H, Hampson M, Gray JR, Constable RT, Papademetris X, Brewer JA. Real-time fMRI links subjective experience with brain activity during focused attention. NeuroImage 2013, 81: 110-118. PMID: 23684866, PMCID: PMC3729617, DOI: 10.1016/j.neuroimage.2013.05.030.Peer-Reviewed Original ResearchConceptsReal-time fMRIPosterior cingulate cortexBrain activitySubjective experienceFocused attentionCingulate cortexCognitive neuroscience researchFocused attention taskOngoing subjective experienceFeedback graphsOwn brain activityDefault mode networkAttention taskNeural processesIntrospective awarenessOngoing taskRt-fMRIAffective functionsExperienced meditatorsMode networkNovel contextNeuroscience researchMeditatorsBrain imagingObjective measures
2012
Intrinsic Brain Connectivity Related to Age in Young and Middle Aged Adults
Hampson M, Tokoglu F, Shen X, Scheinost D, Papademetris X, Constable RT. Intrinsic Brain Connectivity Related to Age in Young and Middle Aged Adults. PLOS ONE 2012, 7: e44067. PMID: 22984460, PMCID: PMC3439483, DOI: 10.1371/journal.pone.0044067.Peer-Reviewed Original ResearchConceptsDefault mode networkIntrinsic brain connectivityAge-related differencesVoxel-based measureEmotional processingRecent developmental studiesState connectivityMode networkCognitive functionBrain scienceVisual areasMiddle-aged adultsFunctional connectivityYoung adulthoodBrain connectivityIndividual tissue elementsCortical regionsDevelopmental studiesHuman brainSubcortical regionsAged adultsPrevious findingsAge-related variationsEarly growth trajectoriesNetwork measures