Assessing a multivariate model of brain-mediated genetic influences on disordered eating in the ABCD cohort
Westwater M, Mallard T, Warrier V, Bethlehem R, Scheinost D, Grillon C, Fletcher P, Seidlitz J, Ernst M. Assessing a multivariate model of brain-mediated genetic influences on disordered eating in the ABCD cohort. Nature Mental Health 2023, 1: 573-585. DOI: 10.1038/s44220-023-00101-4.Peer-Reviewed Original ResearchNeurobiological factorsPsychopathology symptomsFactor scoresCanonical brain networksThree-factor structureStructural equation modelingCritical developmental periodGray matter volumeCortical thicknessGreater genetic riskDisorder symptomatologyABCD studyEarly adolescenceDefault modeBrain networksAnxiety disordersGenetic riskIntervention effortsABCD cohortEquation modelingSubcortical gray matter volumesPsychopathology factorDevelopmental periodFear factorBrain structuresElevated C-reactive protein mediates the liver-brain axis: a preliminary study
Jiang R, Wu J, Rosenblatt M, Dai W, Rodriguez R, Sui J, Qi S, Liang Q, Xu B, Meng Q, Calhoun V, Scheinost D. Elevated C-reactive protein mediates the liver-brain axis: a preliminary study. EBioMedicine 2023, 93: 104679. PMID: 37356206, PMCID: PMC10320521, DOI: 10.1016/j.ebiom.2023.104679.Peer-Reviewed Original ResearchConceptsRegional gray matter volumeGray matter volumeCognitive functioningMost cognitive measuresUnderlying neurobiological factorsEffect sizeLarge effect sizesProspective memoryVisual memoryCognitive measuresExecutive functionTrail MakingCognitive performanceNeurobiological factorsSmall effect sizesProcessing speedVentral striatumParahippocampal gyrusCognitive declineCognitive impairmentMatter volumeMemoryFunctioningCross-sectional associationsLimited research