Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank
Jiang R, Noble S, Sui J, Yoo K, Rosenblatt M, Horien C, Qi S, Liang Q, Sun H, Calhoun V, Scheinost D. Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank. The Lancet Digital Health 2023, 5: e350-e359. PMID: 37061351, PMCID: PMC10257912, DOI: 10.1016/s2589-7500(23)00043-2.Peer-Reviewed Original ResearchConceptsPopulation-based studyPhysical frailtyHealth-related outcomesBrain structuresMental healthHealth outcomesHealth measuresTotal white matter hyperintensitiesIndicators of frailtySeverity of frailtyLower gray matter volumePoor physical fitnessWhite matter hyperintensitiesGray matter volumeUK BiobankHealth-related measuresPoor mental healthMental health measuresDirection of associationMatter hyperintensitiesUnhealthy lifestyleEarly-life risksPsychiatric disordersNumerous confoundersPreventative strategies