2001
Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition
Patel A, Rothman D, Cline G, Behar K. Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Brain Research 2001, 919: 207-220. PMID: 11701133, DOI: 10.1016/s0006-8993(01)03015-3.Peer-Reviewed Original Research
2000
Proton MRS: GABA and glutamate.
Petroff O, Mattson R, Rothman D. Proton MRS: GABA and glutamate. Advances In Neurology 2000, 83: 261-71. PMID: 10999208.Peer-Reviewed Original Research
1999
In vivo chemical shift imaging of γ‐aminobutyric acid in the human brain
Shen J, Shungu D, Rothman D. In vivo chemical shift imaging of γ‐aminobutyric acid in the human brain. Magnetic Resonance In Medicine 1999, 41: 35-42. PMID: 10025609, DOI: 10.1002/(sici)1522-2594(199901)41:1<35::aid-mrm7>3.0.co;2-c.Peer-Reviewed Original ResearchNew NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures.
Petroff O, Behar K, Rothman D. New NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures. Advances In Neurology 1999, 79: 939-45. PMID: 10514877.Peer-Reviewed Original Research
1998
Interpreting functional imaging studies in terms of neurotransmitter cycling
Shulman R, Rothman D. Interpreting functional imaging studies in terms of neurotransmitter cycling. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11993-11998. PMID: 9751778, PMCID: PMC21753, DOI: 10.1073/pnas.95.20.11993.Peer-Reviewed Original ResearchConceptsFunctional imaging experimentsNeurobiological processesFunctional magnetic resonance imagingBasis of neuroscienceSpecific mental processesFunctional imaging studiesFunctional imaging dataVivo 13C NMR measurementsCognitive psychologyCognitive tasksMental processesPsychological termsPsychological interpretationImaging experimentsNeuroscientific interpretationSensory stimulationPsychological designHuman brainFunctional imaging signalsNeurotransmitter cyclingParticular positron emission tomographyNeurotransmitter fluxBrain energy consumptionImaging studiesImaging dataMeasuring human brain GABA in vivo
Petroff O, Rothman D. Measuring human brain GABA in vivo. Molecular Neurobiology 1998, 16: 97-121. PMID: 9554704, DOI: 10.1007/bf02740605.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidGABA concentrationSeizure controlDaily doseRelease of GABACerebrospinal fluid GABA concentrationsGABA synthesisImproved seizure controlComplex partial seizuresPoor seizure controlTraditional antiepileptic drugsSingle oral doseEffects of vigabatrinElevated CSFImportant protective mechanismPartial seizuresOral doseSeizure disorderAntiepileptic drugsNonvesicular releaseSeizure activityGABA levelsTransporter reversalVigabatrinStoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
Sibson N, Dhankhar A, Mason G, Rothman D, Behar K, Shulman R. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 316-321. PMID: 9419373, PMCID: PMC18211, DOI: 10.1073/pnas.95.1.316.Peer-Reviewed Original ResearchConceptsGlutamatergic neuronal activityGlutamate neurotransmitter cyclingNeuronal activityGln synthesisBrain glucose metabolismSynaptic glutamate releaseGlc metabolismGlutamate releaseRat cortexSynaptic activityGlucose metabolismNeuronal functionBrain activation studiesTricarboxylic acid cycleCortexMetabolismAcid cycleActivation studiesAstrocytesNeuronsActivity
1997
Homocarnosine and the measurement of neuronal pH in patients with epilepsy
Rothman D, Behar K, Prichard J, Petroff O. Homocarnosine and the measurement of neuronal pH in patients with epilepsy. Magnetic Resonance In Medicine 1997, 38: 924-929. PMID: 9402193, DOI: 10.1002/mrm.1910380611.Peer-Reviewed Original Research
1996
Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin Therapy
Petroff O, Behar K, Mattson R, Rothman D. Human Brain γ‐Aminobutyric Acid Levels and Seizure Control Following Initiation of Vigabatrin Therapy. Journal Of Neurochemistry 1996, 67: 2399-2404. PMID: 8931472, DOI: 10.1046/j.1471-4159.1996.67062399.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsEpilepsy, Complex PartialFemaleGamma-Aminobutyric AcidHumansMaleMiddle AgedOccipital LobeSeizuresSpectrum AnalysisTime FactorsVigabatrinConceptsBrain GABA contentImproved seizure controlBrain GABA levelsSeizure controlVigabatrin treatmentGABA levelsDaily doseAntiepileptic drugsOccipital lobeBrain gamma-aminobutyric acid (GABA) concentrationsGABA concentrationHuman brain GABA levelsGABA contentGamma-aminobutyric acid concentrationΓ-aminobutyric acid (GABA) levelsComplex partial seizuresNovel antiepileptic drugBrain GABA concentrationsSeizure frequencyPartial seizuresVigabatrin therapySustained elevationHuman occipital lobeGABA synthesisAcid levelsLow brain GABA level is associated with poor seizure control
Petroff O, Rothman D, Behar K, Mattson R. Low brain GABA level is associated with poor seizure control. Annals Of Neurology 1996, 40: 908-911. PMID: 9007096, DOI: 10.1002/ana.410400613.Peer-Reviewed Original ResearchConceptsLower GABA levelsBrain GABA levelsLower brain GABA levelsPoor seizure controlGABA levelsSeizure controlRecent seizuresGamma-aminobutyric acid concentrationComplex partial seizuresPartial seizuresEpileptic syndromesEpileptic focusOccipital lobeCerebrospinal fluidPatientsSeizuresSignificant associationMagnetic resonanceVivo measurementsSurface coilLevelsEpilepsySyndromeGABAAcid concentrationHuman brain GABA levels rise rapidly after initiation of vigabatrin therapy
Petroff O, Rothman D, Behar K, Collins T, Mattson R. Human brain GABA levels rise rapidly after initiation of vigabatrin therapy. Neurology 1996, 47: 1567-1571.. PMID: 8960747, DOI: 10.1212/wnl.47.6.1567.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnticonvulsantsBrainEpilepsyGamma-Aminobutyric AcidHumansMagnetic Resonance SpectroscopyVigabatrinConceptsBrain GABA levelsBrain GABASingle oral doseOral doseGABA levelsSide effectsHuman brain GABA levelsEffective antiepileptic medicationsHours of administrationAntiepileptic medicationsVigabatrin therapyDay dosingIntractable epilepsySerial measurementsOccipital cortexVigabatrinDay 8Day 5GABAGABA transaminasePatientsDoseNext dayHuman brainMagnetic resonance spectroscopyHuman brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose
Petroff O, Rothman D, Behar K, Mattson R. Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose. Neurology 1996, 46: 1459-1463. PMID: 8628502, DOI: 10.1212/wnl.46.5.1459.Peer-Reviewed Original ResearchThe effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy
Petroff O, Rothman D, Behar K, Lamoureux D, Mattson R. The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy. Annals Of Neurology 1996, 39: 95-99. PMID: 8572673, DOI: 10.1002/ana.410390114.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidBrain GABA levelsGABA levelsHuman brain GABA levelsBrain gamma-aminobutyric acidHigh-dose gabapentinAntiepileptic drug treatmentEffect of gabapentinPartial epilepsy patientsTreatment of epilepsyMechanism of actionAdjunctive therapyStandard dosesDrug treatmentEpilepsy patientsOccipital cortexGabapentinPatientsClinical useEpilepsyHuman brainMagnetic resonanceTreatmentMagnetic resonance spectroscopyVivo measurements
1995
Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human Brain
Petroff O, Rothman D, Behar K, Mattson R. Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human Brain. Epilepsia 1995, 36: 457-464. PMID: 7614922, DOI: 10.1111/j.1528-1157.1995.tb00486.x.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidGABA levelsMumol/Antiepileptic drugsOccipital GABA levelsEffective antiepileptic drugEffects of vigabatrinStandard medicationStandard doseΓ-aminobutyric acidHealthy subjectsEpileptic patientsVigabatrinPatientsGABA transaminaseHuman cerebrumNoninvasive measurementHuman brainBrainGlutamateInitial observationsMedicationsCerebrumLevelsDoseVigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy
Mattson R, Petroff O, Rothman D, Behar K. Vigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy. Acta Neurologica Scandinavica. Supplementum 1995, 92: 27-30. PMID: 7495186, DOI: 10.1111/j.1600-0404.1995.tb00496.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBrain GABA levelsGABA levelsBrain concentrationsNerve terminalsAdministration of vigabatrinClear dose-response relationshipLevels of GABAPartial epileptic seizuresAnti-epilepsy drugsPresynaptic nerve terminalsDose-response relationshipConcentration of GABASecondary generalizationClinical effectsClinical outcomesVigabatrin administrationClinical trialsPatient responseClinical studiesSynaptic transmissionBaseline valuesOptimal doseVigabatrin levelsVigabatrinEpileptic seizures
1994
Vigabatrin: Effects on Human Brain GABA Levels by Nuclear Magnetic Resonance Spectroscopy
Mattson R, Petroff O, Rothman D, Behar K. Vigabatrin: Effects on Human Brain GABA Levels by Nuclear Magnetic Resonance Spectroscopy. Epilepsia 1994, 35: s29-s32. PMID: 8039467, DOI: 10.1111/j.1528-1157.1994.tb05963.x.Peer-Reviewed Original ResearchConceptsBrain GABA levelsGABA levelsHuman brain GABA levelsGeneralized tonic-clonic seizuresTonic-clonic seizuresGamma-aminobutyric acid transaminaseNew antiepileptic drugsElevated brain GABA levelsTimes control valuesLong-term trialsDaily dosageAntiepileptic drugsClinical effectsGABA elevationCerebrospinal fluidSide effectsMagnetic resonance spectroscopyControl valuesIrreversible substrateResonance spectroscopyFirst studyDosageConcentrations 2VigabatrinSeizuresAnalysis of macromolecule resonances in 1H NMR spectra of human brain
Behar K, Rothman D, Spencer D, Petroff O. Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magnetic Resonance In Medicine 1994, 32: 294-302. PMID: 7984061, DOI: 10.1002/mrm.1910320304.Peer-Reviewed Original Research
1993
Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.
Rothman D, Petroff O, Behar K, Mattson R. Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 5662-5666. PMID: 8516315, PMCID: PMC46781, DOI: 10.1073/pnas.90.12.5662.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidGABA concentrationGABA-transaminase inhibitor vigabatrinBrain gamma-aminobutyric acidDose-dependent elevationSeizure suppressionOccipital lobeHigh doseNonepileptic subjectsHuman volunteersHuman cortexVigabatrinDrug vigabatrinBrainPatientsHuman brainVolunteersCortexDose
1992
Localized 1H NMR spectra of glutamate in the human brain
Rothman D, Hanstock C, Petroff O, Novotny E, Prichard J, Shulman R. Localized 1H NMR spectra of glutamate in the human brain. Magnetic Resonance In Medicine 1992, 25: 94-106. PMID: 1350656, DOI: 10.1002/mrm.1910250110.Peer-Reviewed Original Research
1984
Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo.
Rothman D, Behar K, Hetherington H, Shulman R. Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6330-6334. PMID: 6149543, PMCID: PMC391917, DOI: 10.1073/pnas.81.20.6330.Peer-Reviewed Original ResearchMeSH KeywordsAlanineAnimalsBrainGamma-Aminobutyric AcidGlutamatesGlutamic AcidLactatesLactic AcidMagnetic Resonance SpectroscopyPostmortem ChangesRadiographyRatsTaurine