2024
Brain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation
Seo D, Martins J, Sinha R. Brain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation. Neurobiology Of Stress 2024, 31: 100645. PMID: 38933283, PMCID: PMC11201348, DOI: 10.1016/j.ynstr.2024.100645.Peer-Reviewed Original ResearchAutonomic nervous system disruptionAlcohol use disorderFunctional magnetic resonance imagingHigh-risk drinkingSocial drinkersFunctional connectivityLow-risk drinkingAlcohol motivationAutonomic arousalDevelopment of alcohol use disordersNeural correlates of stressNon-dependent social drinkersWhole-brain correlation analysesResponse to stress exposureAlcohol taste testFrontal-striatal regionsStress-induced cravingVentromedial prefrontal cortexBehaviors associated with stressAnterior cingulate cortexDecreased functional connectivityExposure to stressAutonomic nervous systemAlcohol intakeHazardous alcohol use
2013
Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk
Seo D, Lacadie CM, Tuit K, Hong KI, Constable RT, Sinha R. Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk. JAMA Psychiatry 2013, 70: 727-739. PMID: 23636842, PMCID: PMC3788824, DOI: 10.1001/jamapsychiatry.2013.762.Peer-Reviewed Original ResearchConceptsHealthy control subjectsAD patientsControl subjectsInpatient treatmentAlcohol cravingAlcohol cuesBrain responsesRelapse riskAlcohol relapseHospital-based research unitAnterior cingulate cortex activationAlcohol-related cuesCommunity mental health centerVentromedial prefrontal functionChronic relapsing illnessVentromedial prefrontal cortexStress-induced cravingAbstinent alcohol-dependent patientsFunctional magnetic resonanceMental health centersAlcohol-dependent patientsSubsequent relapse riskNeural correlatesNeutral trialsHazard ratio